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    Hyi hydroxypyruvate isomerase (putative) [ Mus musculus (house mouse) ]

    Gene ID: 68180, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hyiprovided by MGI
    Official Full Name
    hydroxypyruvate isomerase (putative)provided by MGI
    Primary source
    MGI:MGI:1915430
    See related
    Ensembl:ENSMUSG00000006395 AllianceGenome:MGI:1915430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HT036; 2700033B16Rik; 6430559E15Rik
    Summary
    Predicted to enable hydroxypyruvate isomerase activity. Predicted to be involved in glyoxylate metabolic process. Is expressed in brain and nucleus pulposus. Orthologous to human HYI (hydroxypyruvate isomerase (putative)). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Broad expression in liver adult (RPKM 55.6), adrenal adult (RPKM 46.2) and 27 other tissues See more
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    Genomic context

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    See Hyi in Genome Data Viewer
    Location:
    4 D2.1; 4 54.61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (118217196..118219941)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (118359999..118362744)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type F Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:117930044-117930297 Neighboring gene predicted gene, 40235 Neighboring gene predicted gene, 52705 Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene STARR-positive B cell enhancer ABC_E1281 Neighboring gene mediator complex subunit 8 Neighboring gene ELOVL fatty acid elongase 1 Neighboring gene cell division cycle 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Szt2, a novel gene for seizure threshold in mice. Frankel WN, et al. Genes Brain Behav, 2009 Jul. PMID 19624305, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydroxypyruvate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxypyruvate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glyoxylate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative hydroxypyruvate isomerase
    Names
    hydroxypyruvate isomerase homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026601.3 → NP_080877.3  putative hydroxypyruvate isomerase

      See identical proteins and their annotated locations for NP_080877.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the coding variant that is expressed in some strains, including FBV/N, CZECHII, and CD-1.
      Source sequence(s)
      AA403499, BC024619
      UniProtKB/Swiss-Prot
      A2A9C1, Q497S8, Q8R1F5
      Conserved Domains (3) summary
      COG3622
      Location:3 → 266
      Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
      pfam01261
      Location:24 → 219
      AP_endonuc_2; Xylose isomerase-like TIM barrel
      cl02563
      Location:209 → 270
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RNA

    1. NR_003946.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, non-coding) lacks an exon resulting in a frameshift. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant appears to only be expressed in the C57BL/6 strain, which also contains a short deletion in the alternatively spliced exon.
      Source sequence(s)
      AK020099, BE996398, CB952524, CK620463
      Related
      ENSMUST00000106393.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      118217196..118219941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1F5.2 GenPept UniProtKB/Swiss-Prot:Q8R1F5

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