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    Brca1 BRCA1 DNA repair associated [ Chinchilla lanigera (long-tailed chinchilla) ]

    Gene ID: 102029928, updated on 16-Nov-2024

    Summary

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    Gene symbol
    Brca1
    Gene description
    BRCA1 DNA repair associated
    See related
    Ensembl:ENSCLAG00000017210 RGD:8979663
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Chinchilla lanigera
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Chinchillidae; Chinchilla
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See Brca1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    101 current ChiLan1.0 (GCF_000276665.1) Unplaced Scaffold NW_004955451.1 (16819463..16870780, complement)

    NW_004955451.1Genomic Context describing neighboring genes Neighboring gene interferon induced protein 35 Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene transmembrane protein 106A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004955451.1 Unplaced Scaffold Reference ChiLan1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chordate embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dosage compensation by inactivation of X chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BRCA1-A complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of BRCA1-BARD1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast cancer type 1 susceptibility protein
    Names
    breast and ovarian cancer susceptibility 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Chinchilla lanigera Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ChiLan1.0 Primary Assembly

    Genomic

    1. NW_004955451.1 Reference ChiLan1.0 Primary Assembly

      Range
      16819463..16870780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013519230.1 → XP_013374684.1  breast cancer type 1 susceptibility protein isoform X2

      UniProtKB/TrEMBL
      A0A8C2YUW0
      Related
      ENSCLAP00000025064.1, ENSCLAT00000025308.1
      Conserved Domains (4) summary
      smart00292
      Location:1727 → 1812
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1619 → 1693
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:28 → 73
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12820
      Location:352 → 515
      BRCT_assoc; Serine-rich domain associated with BRCT

    2. XM_005394496.2 → XP_005394553.2  breast cancer type 1 susceptibility protein isoform X3

      UniProtKB/TrEMBL
      A0A8C2YUW0
      Conserved Domains (4) summary
      smart00292
      Location:1728 → 1812
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1620 → 1694
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:28 → 73
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12820
      Location:352 → 515
      BRCT_assoc; Serine-rich domain associated with BRCT

    3. XM_013519228.1 → XP_013374682.1  breast cancer type 1 susceptibility protein isoform X1

      UniProtKB/TrEMBL
      A0A8C2YUW0
      Conserved Domains (4) summary
      smart00292
      Location:1728 → 1813
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1620 → 1694
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:28 → 73
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12820
      Location:352 → 515
      BRCT_assoc; Serine-rich domain associated with BRCT

    4. XM_013519229.1 → XP_013374683.1  breast cancer type 1 susceptibility protein isoform X1

      UniProtKB/TrEMBL
      A0A8C2YUW0
      Conserved Domains (4) summary
      smart00292
      Location:1728 → 1813
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1620 → 1694
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:28 → 73
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12820
      Location:352 → 515
      BRCT_assoc; Serine-rich domain associated with BRCT

    5. XM_013519231.1 → XP_013374685.1  breast cancer type 1 susceptibility protein isoform X4

      UniProtKB/TrEMBL
      A0A8C2W4H3
      Related
      ENSCLAP00000025065.1, ENSCLAT00000025309.1
      Conserved Domains (4) summary
      smart00292
      Location:1728 → 1767
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1620 → 1694
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:28 → 73
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12820
      Location:352 → 515
      BRCT_assoc; Serine-rich domain associated with BRCT

    RNA

    1. XR_001235969.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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