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    Alox12e arachidonate lipoxygenase, epidermal [ Mus musculus (house mouse) ]

    Gene ID: 11685, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Alox12eprovided by MGI
    Official Full Name
    arachidonate lipoxygenase, epidermalprovided by MGI
    Primary source
    MGI:MGI:1274790
    See related
    Ensembl:ENSMUSG00000018907 AllianceGenome:MGI:1274790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8-LOX; Aloxe; 12-LOX; e-LOX1; 12-LOX-e; Alox12-ps1; Alox12-ps2
    Summary
    Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in arachidonate metabolic process and lipoxygenase pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Is expressed in alimentary system; hemolymphoid system; integumental system; and respiratory system. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 12.1), ovary adult (RPKM 7.2) and 3 other tissues See more
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    Genomic context

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    See Alox12e in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70206436..70213545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70315610..70322720, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33048 Neighboring gene predicted gene, 40192 Neighboring gene arachidonate 15-lipoxygenase Neighboring gene STARR-seq mESC enhancer starr_29874 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29875 Neighboring gene STARR-seq mESC enhancer starr_29876 Neighboring gene proline, glutamic acid and leucine rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Senescence-associated tumor growth is promoted by 12-Lipoxygenase. Patil S, et al. Aging (Albany NY), 2022 Feb 14. PMID 35158337, Free PMC Article
    2. Functional expression and cellular localization of a mouse epidermal lipoxygenase. Funk CD, et al. J Biol Chem, 1996 Sep 20. PMID 8798535
    3. Murine epidermal lipoxygenase (Aloxe) encodes a 12-lipoxygenase isoform. Kinzig A, et al. FEBS Lett, 1997 Feb 3. PMID 9037187
    4. Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene. Kim E, et al. J Biol Chem, 2004 Mar 19. PMID 14711820
    5. Genomic and cDNA cloning of a novel mouse lipoxygenase gene. van Dijk KW, et al. Biochim Biophys Acta, 1995 Oct 26. PMID 7492614

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Senescence-associated tumor growth is promoted by 12-Lipoxygenase.
      Title: Senescence-associated tumor growth is promoted by 12-Lipoxygenase.
    2. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
      Title: 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
    3. these results suggest that the MaR1/RORalpha/12-LOX autoregulatory circuit could offer potential therapeutic strategies for curing NASH.
      Title: A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis.
    4. identification and characterization of a phorbol ester-responsive element
      Title: Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate 12(S)-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate 12(S)-lipoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arachidonate 15-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables linoleate 13S-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables linoleate 13S-lipoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipoxygenase pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type
    Names
    arachidonate (12S)-lipoxygenase, epidermal-type
    arachidonate 12-lipoxygenase, epidermal
    arachidonate 12-lipoxygenase, epidermal-type
    e(12S)-LOX
    linoleate (13S)-lipoxygenase
    NP_663717.1
    XP_006532097.1
    XP_006532098.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145684.2 → NP_663717.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type

      See identical proteins and their annotated locations for NP_663717.1

      Status: VALIDATED

      Source sequence(s)
      AK138743, AL596096, BX630350
      Consensus CDS
      CCDS24943.1
      UniProtKB/Swiss-Prot
      P55249, Q91YW6
      UniProtKB/TrEMBL
      Q5F2E4
      Related
      ENSMUSP00000019051.3, ENSMUST00000019051.3
      Conserved Domains (2) summary
      cd01753
      Location:2 → 111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:169 → 653
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70206436..70213545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532035.4 → XP_006532098.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X2

      See identical proteins and their annotated locations for XP_006532098.1

      Conserved Domains (2) summary
      cd01753
      Location:35 → 143
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:193 → 685
      Lipoxygenase

    2. XM_006532034.5 → XP_006532097.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X1

      See identical proteins and their annotated locations for XP_006532097.1

      Conserved Domains (2) summary
      cd01753
      Location:35 → 144
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:194 → 686
      Lipoxygenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55249.1 GenPept UniProtKB/Swiss-Prot:P55249

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