NR2C2 nuclear receptor subfamily 2 group C member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NR2C2provided by HGNC
Official Full Name: nuclear receptor subfamily 2 group C member 2provided by HGNC
Primary source: HGNC:HGNC:7972
See related: Ensembl:ENSG00000177463 MIM:601426; AllianceGenome:HGNC:7972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TR4; TAK1
Summary: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression: Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 9.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p25.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (14947583..15049273)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (14950033..15051696)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (14989090..15090780)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
Title: Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
TR4 worsen urosepsis by regulating GSDMD.
Title: TR4 worsen urosepsis by regulating GSDMD.
Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
Title: Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
Title: HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Title: Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
Title: Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
The stabilization of yes-associated protein by TGFbeta-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
Title: The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.
Title: Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.
Use of miR145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer.
Title: Use of miR‑145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer.
LncRNA H19 aggravates TNF-alpha-induced inflammatory injury via TAK1 pathway in MH7A cells.
Title: LncRNA H19 aggravates TNF-α-induced inflammatory injury via TAK1 pathway in MH7A cells.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:312714 (e-PCR)
- UniSTS:156429

D10S275 (e-PCR)
- UniSTS:147992

RH94219 (e-PCR)
- UniSTS:90912

NR2C2_2354 (e-PCR)
- UniSTS:280875

D11S3688 (e-PCR)
- UniSTS:152919

SHGC-76739 (e-PCR)
- UniSTS:15978

STS-R79814 (e-PCR)
- UniSTS:69494

STS-T71249 (e-PCR)
- UniSTS:60038

L17971 (e-PCR)
- UniSTS:43966

D3S3339 (e-PCR)
- UniSTS:963

RH119206 (e-PCR)
- UniSTS:138715

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of embryonic development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: nuclear receptor subfamily 2 group C member 2

Names: Nuclear hormone receptor TR4; orphan nuclear receptor TAK1; orphan nuclear receptor TR4; orphan receptor TR4; testicular nuclear receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291694.2 → NP_001278623.1 nuclear receptor subfamily 2 group C member 2 isoform 2

See identical proteins and their annotated locations for NP_001278623.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC090937, AC090954, AI986459, AK290590

Consensus CDS

CCDS74905.1

UniProtKB/Swiss-Prot

A8K3H5, B6ZGT8, P49116, P55092

UniProtKB/TrEMBL

Q6PHZ7

Related

ENSP00000388387.1, ENST00000425241.6

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
NM_003298.5 → NP_003289.2 nuclear receptor subfamily 2 group C member 2 isoform 1

See identical proteins and their annotated locations for NP_003289.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC090937, AC090954, AI986459, AK290590, L27586

Consensus CDS

CCDS2621.1

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2, Q6PHZ7

Related

ENSP00000320447.6, ENST00000323373.10

Conserved Domains (2) summary

cd06952
Location:380 → 601

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:131 → 217

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

14947583..15049273

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448826.1 → XP_047304782.1 nuclear receptor subfamily 2 group C member 2 isoform X1

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448825.1 → XP_047304781.1 nuclear receptor subfamily 2 group C member 2 isoform X1

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448830.1 → XP_047304786.1 nuclear receptor subfamily 2 group C member 2 isoform X3
XM_047448829.1 → XP_047304785.1 nuclear receptor subfamily 2 group C member 2 isoform X2
XM_011534058.4 → XP_011532360.1 nuclear receptor subfamily 2 group C member 2 isoform X1

See identical proteins and their annotated locations for XP_011532360.1

UniProtKB/TrEMBL

Q6PHZ7

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448836.1 → XP_047304792.1 nuclear receptor subfamily 2 group C member 2 isoform X7
XM_011534063.4 → XP_011532365.1 nuclear receptor subfamily 2 group C member 2 isoform X3

See identical proteins and their annotated locations for XP_011532365.1

Conserved Domains (2) summary

cd06952
Location:394 → 615

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:145 → 231

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_011534064.4 → XP_011532366.1 nuclear receptor subfamily 2 group C member 2 isoform X5

See identical proteins and their annotated locations for XP_011532366.1

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2, Q6PHZ7

Conserved Domains (2) summary

cd06952
Location:380 → 601

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:131 → 217

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448827.1 → XP_047304783.1 nuclear receptor subfamily 2 group C member 2 isoform X1

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_011534065.4 → XP_011532367.1 nuclear receptor subfamily 2 group C member 2 isoform X5

See identical proteins and their annotated locations for XP_011532367.1

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2, Q6PHZ7

Conserved Domains (2) summary

cd06952
Location:380 → 601

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:131 → 217

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_011534061.4 → XP_011532363.1 nuclear receptor subfamily 2 group C member 2 isoform X1

See identical proteins and their annotated locations for XP_011532363.1

UniProtKB/TrEMBL

Q6PHZ7

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448837.1 → XP_047304793.1 nuclear receptor subfamily 2 group C member 2 isoform X7
XM_047448832.1 → XP_047304788.1 nuclear receptor subfamily 2 group C member 2 isoform X3
XM_047448838.1 → XP_047304794.1 nuclear receptor subfamily 2 group C member 2 isoform X8
XM_047448835.1 → XP_047304791.1 nuclear receptor subfamily 2 group C member 2 isoform X6
XM_011534059.3 → XP_011532361.1 nuclear receptor subfamily 2 group C member 2 isoform X1

See identical proteins and their annotated locations for XP_011532361.1

UniProtKB/TrEMBL

Q6PHZ7

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448831.1 → XP_047304787.1 nuclear receptor subfamily 2 group C member 2 isoform X3
XM_047448828.1 → XP_047304784.1 nuclear receptor subfamily 2 group C member 2 isoform X1

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448824.1 → XP_047304780.1 nuclear receptor subfamily 2 group C member 2 isoform X1

Conserved Domains (2) summary

cd06952
Location:413 → 634

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:164 → 250

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448834.1 → XP_047304790.1 nuclear receptor subfamily 2 group C member 2 isoform X5

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2

Related

ENSP00000483059.1, ENST00000617312.4
XM_011534066.4 → XP_011532368.1 nuclear receptor subfamily 2 group C member 2 isoform X5

See identical proteins and their annotated locations for XP_011532368.1

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2, Q6PHZ7

Conserved Domains (2) summary

cd06952
Location:380 → 601

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:131 → 217

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_047448833.1 → XP_047304789.1 nuclear receptor subfamily 2 group C member 2 isoform X4
XM_024453739.2 → XP_024309507.1 nuclear receptor subfamily 2 group C member 2 isoform X9

Conserved Domains (2) summary

cd06952
Location:182 → 403

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cl02596
Location:1 → 19

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

14950033..15051696

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054347716.1 → XP_054203691.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347714.1 → XP_054203689.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347721.1 → XP_054203696.1 nuclear receptor subfamily 2 group C member 2 isoform X3
XM_054347719.1 → XP_054203694.1 nuclear receptor subfamily 2 group C member 2 isoform X2
XM_054347711.1 → XP_054203686.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347728.1 → XP_054203703.1 nuclear receptor subfamily 2 group C member 2 isoform X7
XM_054347720.1 → XP_054203695.1 nuclear receptor subfamily 2 group C member 2 isoform X3
XM_054347724.1 → XP_054203699.1 nuclear receptor subfamily 2 group C member 2 isoform X5

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2
XM_054347717.1 → XP_054203692.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347725.1 → XP_054203700.1 nuclear receptor subfamily 2 group C member 2 isoform X5

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2
XM_054347713.1 → XP_054203688.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347729.1 → XP_054203704.1 nuclear receptor subfamily 2 group C member 2 isoform X7
XM_054347723.1 → XP_054203698.1 nuclear receptor subfamily 2 group C member 2 isoform X3
XM_054347730.1 → XP_054203705.1 nuclear receptor subfamily 2 group C member 2 isoform X8
XM_054347727.1 → XP_054203702.1 nuclear receptor subfamily 2 group C member 2 isoform X6
XM_054347715.1 → XP_054203690.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347722.1 → XP_054203697.1 nuclear receptor subfamily 2 group C member 2 isoform X3
XM_054347718.1 → XP_054203693.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347712.1 → XP_054203687.1 nuclear receptor subfamily 2 group C member 2 isoform X1
XM_054347726.1 → XP_054203701.1 nuclear receptor subfamily 2 group C member 2 isoform X5

UniProtKB/TrEMBL

A0A024R2N9, F2YGU2
XM_054347731.1 → XP_054203706.1 nuclear receptor subfamily 2 group C member 2 isoform X9