U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    SCGB2A1 secretoglobin family 2A member 1 [ Homo sapiens (human) ]

    Gene ID: 4246, updated on 2-Nov-2024

    Summary

    Official Symbol
    SCGB2A1provided by HGNC
    Official Full Name
    secretoglobin family 2A member 1provided by HGNC
    Primary source
    HGNC:HGNC:7051
    See related
    Ensembl:ENSG00000124939 MIM:604398; AllianceGenome:HGNC:7051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPHC; LPNC; MGB2; UGB3
    Summary
    Involved in androgen receptor signaling pathway. Located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in endometrium (RPKM 28.0), stomach (RPKM 15.9) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SCGB2A1 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62208673..62213943)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62197948..62203186)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61976145..61981415)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61942903-61943082 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61959742-61960242 Neighboring gene secretoglobin family 1D member 1 Neighboring gene secretoglobin family 1D member 2 Neighboring gene secretoglobin family 2A member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Mammaglobin, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC71973

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mammaglobin-B
    Names
    lacryglobin
    lipophilin C
    mammaglobin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002407.3NP_002398.1  mammaglobin-B precursor

      See identical proteins and their annotated locations for NP_002398.1

      Status: VALIDATED

      Source sequence(s)
      AF071219, AJ224173, AP003306, BC062218
      Consensus CDS
      CCDS8016.1
      UniProtKB/Swiss-Prot
      O75556
      Related
      ENSP00000244930.4, ENST00000244930.6
      Conserved Domains (1) summary
      pfam01099
      Location:2290
      Uteroglobin; Uteroglobin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62208673..62213943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62197948..62203186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)