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    daf-8 Smad protein daf-8 [ Caenorhabditis elegans ]

    Gene ID: 187612, updated on 12-Jun-2024

    Summary

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    Gene symbol
    daf-8
    Gene description
    Smad protein daf-8
    Locus tag
    CELE_R05D11.1
    See related
    AllianceGenome:WB:WBGene00000904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including dauer entry; oviposition; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in excretory cell; hermaphrodite distal tip cell; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; cervical cancer; ovarian cancer; and pancreatic cancer. Orthologous to human SMAD2 (SMAD family member 2) and SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See daf-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (8584424..8587507, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene L-serine ammonia-lyase Neighboring gene Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase Neighboring gene putative nuclear transport factor 2 Neighboring gene Transmembrane protein 208

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cut-1 a Caenorhabditis elegans gene coding for a dauer-specific noncollagenous component of the cuticle. Sebastiano M, et al. Dev Biol, 1991 Aug. PMID 1864469
    2. The DAF-7/TGF-β signaling pathway regulates abundance of the Caenorhabditis elegans glutamate receptor GLR-1. McGehee AM, et al. Mol Cell Neurosci, 2015 Jul. PMID 26054666, Free PMC Article
    3. Control of C. elegans larval development by neuronal expression of a TGF-beta homolog. Ren P, et al. Science, 1996 Nov 22. PMID 8910282
    4. Transcriptomic Profiling of DAF-7/TGFβ Pathway Mutants in C. elegans. Hu M, et al. Genes (Basel), 2020 Mar 9. PMID 32182864, Free PMC Article
    5. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Schackwitz WS, et al. Neuron, 1996 Oct. PMID 8893028

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pigment accumulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of multicellular organismal process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heteromeric SMAD protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smad protein daf-8
    NP_492321.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8584424..8587507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059920.6 → NP_492321.1  Smad protein daf-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21733
      Conserved Domains (2) summary
      smart00524
      Location:348 → 522
      DWB; Domain B in dwarfin family proteins
      smart00523
      Location:32 → 135
      DWA; Domain A in dwarfin family proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21733.1

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