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    rict-1 RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565035, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rict-1
    Official Full Name
    RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein
    Primary source
    WormBase:WBGene00009245
    Locus tag
    CELE_F29C12.3
    See related
    AllianceGenome:WB:WBGene00009245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Involved in mesendoderm development. Part of TORC2 complex. Is expressed in several structures, including head neurons; intestine; pharynx; spermatheca; and ventral nerve cord. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rict-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (13098239..13116810, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene DUF3444 domain-containing protein Neighboring gene Eukaryotic translation initiation factor 2-alpha kinase gcn-2 Neighboring gene DUF19 domain-containing protein Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene Elongation factor G, mitochondrial Neighboring gene BTB and MATH domain-containing protein 45

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans. Aspernig H, et al. Cell Rep, 2019 Nov 5. PMID 31693882
    2. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. Yen K, et al. PLoS One, 2010 Sep 16. PMID 20862331, Free PMC Article
    3. mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity. Mizunuma M, et al. Aging Cell, 2014 Oct. PMID 25040785, Free PMC Article
    4. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. O'Donnell MP, et al. PLoS Genet, 2018 Feb. PMID 29415022, Free PMC Article
    5. The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in C. elegans. Breen PC, et al. Front Cell Dev Biol, 2024. PMID 38946799, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mesendoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein
    NP_001254376.1
    • Confirmed by transcript evidence
    NP_001254377.1
    • Confirmed by transcript evidence
    NP_001254378.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13098239..13116810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267447.2 → NP_001254376.1  RICTOR_N domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFK2
      Conserved Domains (4) summary
      pfam14663
      Location:890 → 991
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:94 → 499
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:783 → 883
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:1055 → 1121
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. NM_001267448.2 → NP_001254377.1  RICTOR_N domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN2
      Conserved Domains (4) summary
      pfam14663
      Location:892 → 993
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:94 → 501
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:785 → 885
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:1057 → 1123
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. NM_001267449.3 → NP_001254378.1  Rapamycin-insensitive companion of mTOR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED67
      Conserved Domains (3) summary
      pfam14663
      Location:80 → 181
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14666
      Location:2 → 73
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:245 → 311
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    Nucleotide Protein
    Heading Accession and Version

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