micu-3 EF-hand domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: micu-3
Official Full Name: EF-hand domain-containing protein
Primary source: WormBase:WBGene00008345
Locus tag: CELE_C56A3.6
See related: AllianceGenome:WB:WBGene00008345
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be part of uniplex complex. Orthologous to several human genes including MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See micu-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (13553379..13556397, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

C56A3.6 (e-PCR)
- UniSTS:319173

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EF-hand domain-containing protein

NP_001256519.1

Confirmed by transcript evidence

NP_001256520.1

Partially confirmed by transcript evidence

NP_001256521.1

Confirmed by transcript evidence

NP_001256522.1

Partially confirmed by transcript evidence

NP_001360534.1

Partially confirmed by transcript evidence

NP_001360535.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13553379..13556397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269591.3 → NP_001256520.1 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256520.1

Status: REVIEWED

UniProtKB/TrEMBL

D9N138

Conserved Domains (3) summary

smart00054
Location:363 → 386

EFh; EF-hand, calcium binding motif

pfam13499
Location:174 → 247

EF-hand_7; EF-hand domain pair

cl08302
Location:171 → 246

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001269592.3 → NP_001256521.1 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256521.1

Status: REVIEWED

UniProtKB/TrEMBL

D9N139

Conserved Domains (2) summary

smart00054
Location:404 → 427

EFh; EF-hand, calcium binding motif

cl08302
Location:140 → 192

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001373146.2 → NP_001360534.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WVK8

Conserved Domains (2) summary

cd15900
Location:172 → 391

EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

cl08302
Location:142 → 194

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001373147.2 → NP_001360535.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WWU3

Conserved Domains (2) summary

cd15900
Location:172 → 432

EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

cl08302
Location:142 → 194

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001269593.3 → NP_001256522.1 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256522.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18874

Conserved Domains (2) summary

cd15900
Location:170 → 449

EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

cl08302
Location:140 → 192

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001269590.3 → NP_001256519.1 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256519.1

Status: REVIEWED

UniProtKB/TrEMBL

D7SFN6

Conserved Domains (3) summary

smart00054
Location:344 → 367

EFh; EF-hand, calcium binding motif

pfam13499
Location:174 → 228

EF-hand_7; EF-hand domain pair

cl08302
Location:171 → 227

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...