slo-1 BK channel;Calcium-activated potassium channel slo-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: slo-1
Official Full Name: BK channel;Calcium-activated potassium channel slo-1
Primary source: WormBase:WBGene00004830
Locus tag: CELE_Y51A2D.19
See related: AllianceGenome:WB:WBGene00004830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium-activated potassium channel activity and voltage-gated potassium channel activity. Involved in several processes, including behavioral response to ethanol; nematode pharyngeal pumping; and sarcomere organization. Located in M band; striated muscle dense body; and synapse. Is expressed in several structures, including AWC; body wall musculature; non-striated muscle; pharyngeal neurons; and somatic nervous system. Used to study Duchenne muscular dystrophy and alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; idiopathic generalized epilepsy; paroxysmal nonkinesigenic dyskinesia 3; and spermatogenic failure 79. Orthologous to several human genes including KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See slo-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 23

Sequence:: Chromosome: V; NC_003283.11 (18492261..18508212)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melatonin promotes sleep by activating the BK channel in C. elegans.
Title: Melatonin promotes sleep by activating the BK channel in C. elegans.
BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor.
Title: BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor.
The authors show that ERG-28, an endoplasmic reticulum (ER) membrane protein, promotes the trafficking of SLO-1 BK channels from the ER to the plasma membrane by shielding them from premature degradation.
Title: ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans.
Enhanced SLO-1 function, via gain-of-function mutation or overexpression, dramatically reduced behavioral impairment during ethanol withdrawal.
Title: Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in Caenorhabditis elegans.
SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry.
Title: SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.
SLO-1 potassium channels distinctively form organized clusters at presynaptic terminals; two cytoskeletal proteins, CTN-1 and DYB-1, are crucial for normal SLO-1 cluster formation
Title: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.
This study demonistrated that the T352I mutation selectively disrupts ethanol modulation of the BK channel.
Title: Conserved single residue in the BK potassium channel required for activation by alcohol and intoxication in C. elegans.
This study shows cellular and whole organismal behavioral responses to ethanol in C. elegans that directly equate to intoxicating through to supralethal blood alcohol concentrations in humans.
Title: Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans.
an interaction between BK and EAG family K(+) channels produces the muscle excitability levels that regulate the timing of spicule protraction and the success of male mating behavior.
Title: Cell excitability necessary for male mating behavior in Caenorhabditis elegans is coordinated by interactions between big current and ether-a-go-go family K(+) channels.
slo-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans
Title: Ethanol interferes with gustatory plasticity in Caenorhabditis elegans.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables large conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BK channel;Calcium-activated potassium channel slo-1

NP_001024259.1

Confirmed by transcript evidence

NP_001024260.1

Confirmed by transcript evidence

NP_001024261.1

Confirmed by transcript evidence

NP_001256801.1

Confirmed by transcript evidence

NP_001256802.1

Confirmed by transcript evidence

NP_001256803.1

Confirmed by transcript evidence

NP_001256804.1

Confirmed by transcript evidence

NP_001256805.1

Confirmed by transcript evidence

NP_001256806.1

Confirmed by transcript evidence

NP_001256807.1

Confirmed by transcript evidence

NP_001256808.1

Confirmed by transcript evidence

NP_001256809.1

Confirmed by transcript evidence

NP_001256810.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

18492261..18508212

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269875.4 → NP_001256804.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256804.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM4, H7BRM6

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001029090.5 → NP_001024261.1 Calcium-activated potassium channel slo-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024261.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM6

Conserved Domains (3) summary

pfam00520
Location:173 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:270 → 355

Ion_trans_2; Ion channel
NM_001269879.4 → NP_001256808.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256808.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM3, H8ESD8

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001029089.3 → NP_001024260.1 Calcium-activated potassium channel slo-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024260.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM6

Conserved Domains (3) summary

pfam00520
Location:173 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:270 → 355

Ion_trans_2; Ion channel
NM_001029088.2 → NP_001024259.1 Calcium-activated potassium channel slo-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024259.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95V25, Q95V26, Q95V27, Q9U268

UniProtKB/TrEMBL

H7BRM6

Conserved Domains (3) summary

pfam00520
Location:173 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:270 → 355

Ion_trans_2; Ion channel
NM_001269873.3 → NP_001256802.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256802.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRC9, H7BRM3

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001269872.3 → NP_001256801.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256801.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM6, H8ESD6

Conserved Domains (2) summary

pfam00520
Location:154 → 375

Ion_trans; Ion transport protein

pfam03493
Location:524 → 599

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001269874.3 → NP_001256803.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256803.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM3, H8ESE4

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001269876.3 → NP_001256805.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256805.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM6, H8ESE5

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001269877.3 → NP_001256806.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256806.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM5, H7BRM6

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001269878.3 → NP_001256807.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256807.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM3, H8ESE2

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001269880.3 → NP_001256809.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256809.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM6, H8ESE3

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit
NM_001269881.3 → NP_001256810.1 BK channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256810.1

Status: REVIEWED

UniProtKB/TrEMBL

H7BRM6, H7BRM7

Conserved Domains (2) summary

pfam00520
Location:139 → 360

Ion_trans; Ion transport protein

pfam03493
Location:509 → 584

BK_channel_a; Calcium-activated BK potassium channel alpha subunit