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    Atg101 autophagy related 101 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300240, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atg101provided by RGD
    Official Full Name
    autophagy related 101provided by RGD
    Primary source
    RGD:1359310
    See related
    EnsemblRapid:ENSRNOG00000007756 AllianceGenome:RGD:1359310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1359310
    Summary
    Predicted to enable identical protein binding activity and protein kinase binding activity. Predicted to be involved in several processes, including autophagosome assembly; positive regulation of autophagy; and regulation of protein lipidation. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in phagophore assembly site. Orthologous to human ATG101 (autophagy related 101). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 167.3), Adrenal (RPKM 131.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atg101 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134277223..134286387)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132398477..132407643)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142929381..142938559)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479787 Neighboring gene uncharacterized LOC134479786 Neighboring gene nuclear receptor subfamily 4, group A, member 1 Neighboring gene small integral membrane protein 41 Neighboring gene keratin 80

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy. Zhang ZJ, et al. Front Pharmacol, 2022. PMID 35592424, Free PMC Article
    2. Development and validation of prognostic model based on the analysis of autophagy-related genes in colon cancer. Wang Y, et al. Aging (Albany NY), 2021 Jul 27. PMID 34315829, Free PMC Article
    3. Atg101, a novel mammalian autophagy protein interacting with Atg13. Hosokawa N, et al. Autophagy, 2009 Oct. PMID 19597335
    4. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94201

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein lipidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Atg1/ULK1 kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Atg1/ULK1 kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    autophagy-related protein 101

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007659.2 → NP_001007660.2  autophagy-related protein 101 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC079170, JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8L2Q495, A0A8L2R4A7
      Related
      ENSRNOP00000010195.3, ENSRNOT00000010194.5
      Conserved Domains (1) summary
      pfam07855
      Location:54 → 217
      DUF1649; Protein of unknown function (DUF1649)

    2. NM_001271114.1 → NP_001258043.1  autophagy-related protein 101 isoform 2

      See identical proteins and their annotated locations for NP_001258043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BU670996, JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q6AY69
      UniProtKB/TrEMBL
      A0A8L2R4A7, A6KCP1
      Conserved Domains (1) summary
      pfam07855
      Location:9 → 172
      ATG101; Autophagy-related protein 101

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134277223..134286387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242324.5 → XP_006242386.1  autophagy-related protein 101 isoform X1

      See identical proteins and their annotated locations for XP_006242386.1

      UniProtKB/Swiss-Prot
      Q6AY69
      UniProtKB/TrEMBL
      A0A8L2R4A7, A6KCP1
      Conserved Domains (1) summary
      pfam07855
      Location:9 → 172
      ATG101; Autophagy-related protein 101
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY69.1 GenPept UniProtKB/Swiss-Prot:Q6AY69

    Gene LinkOut

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