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    atg7 E1 Atg8 and Atg12 E1 activating enzyme Atg7 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540790, updated on 18-Sep-2024

    Summary

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    Official Symbol
    atg7
    Official Full Name
    E1 Atg8 and Atg12 E1 activating enzyme Atg7
    Primary source
    PomBase:SPBC6B1.05c
    Locus tag
    SPOM_SPBC6B1.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See atg7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003423.3 (2634227..2636608, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene microtubule-site clamp monopolin complex subunit Mde4 Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp14 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic regulation of mitotic competence in G(0) quiescent cells. Sajiki K, et al. Sci Adv, 2018 Aug. PMID 30116786, Free PMC Article
    2. Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance. Mikawa T, et al. Genes Cells, 2010 Mar. PMID 20070859
    3. Autophagy is required for efficient meiosis progression and proper meiotic chromosome segregation in fission yeast. Matsuhara H, et al. Genes Cells, 2016 Jan. PMID 26696398
    4. Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast. Sawada N, et al. J Biol Chem, 2021 Jul. PMID 34147496, Free PMC Article
    5. Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation. Mukaiyama H, et al. Microbiology (Reading), 2009 Dec. PMID 19778961

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables Atg12 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Atg8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E1 Atg8 and Atg12 E1 activating enzyme Atg7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2634227..2636608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021998.3 → NP_596084.1  E1 Atg8 and Atg12 E1 activating enzyme Atg7 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596084.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O43069
      Conserved Domains (3) summary
      cd01486
      Location:337 → 624
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:9 → 646
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:7 → 300
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    Nucleotide Protein
    Heading Accession and Version

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