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    end4 clathrin adaptor End4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543336, updated on 18-Sep-2024

    Summary

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    Official Symbol
    end4
    Official Full Name
    clathrin adaptor End4
    Primary source
    PomBase:SPAC688.11
    Locus tag
    SPOM_SPAC688.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    sla2
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    Genomic context

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    See end4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3134987..3138666)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial pyrimidine nucleotide transporter Neighboring gene DNA polymerase zeta catalytic subunit Rev3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene TatD DNase family Scn1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe. Castagnetti S, et al. J Cell Sci, 2005 May 1. PMID 15827087
    2. Characterization of end4+, a gene required for endocytosis in Schizosaccharomyces pombe. Iwaki T, et al. Yeast, 2004 Jul 30. PMID 15300681
    3. Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches. Chen Q, et al. Curr Biol, 2013 Jul 8. PMID 23727096, Free PMC Article
    4. Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth. Alvarez-Tabarés I, et al. J Cell Sci, 2007 Oct 15. PMID 17895368
    5. The novel fission yeast protein Pal1p interacts with Hip1-related Sla2p/End4p and is involved in cellular morphogenesis. Ge W, et al. Mol Biol Cell, 2005 Sep. PMID 15975911, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal protein-membrane anchor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm HDA PubMed 
    is_active_in endocytic patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in new growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in old growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    clathrin adaptor End4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3134987..3138666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019493.3 → NP_594069.2  clathrin adaptor End4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594069.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78916, Q9P6L5
      Conserved Domains (3) summary
      smart00307
      Location:902 → 1100
      ILWEQ; I/LWEQ domain
      pfam07651
      Location:14 → 281
      ANTH; ANTH domain
      pfam13851
      Location:468 → 621
      GAS; Growth-arrest specific micro-tubule binding
    Nucleotide Protein
    Heading Accession and Version

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