U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Itga7 integrin alpha 7 [ Mus musculus (house mouse) ]

    Gene ID: 16404, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Itga7provided by MGI
    Official Full Name
    integrin alpha 7provided by MGI
    Primary source
    MGI:MGI:102700
    See related
    Ensembl:ENSMUSG00000025348 AllianceGenome:MGI:102700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [a]7; alpha7
    Summary
    This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 28.3), heart adult (RPKM 26.2) and 21 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Itga7 in Genome Data Viewer
    Location:
    10 D3; 10 77.2 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128769633..128794155)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128933421..128958286)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene CD63 antigen Neighboring gene STARR-positive B cell enhancer ABC_E6941 Neighboring gene retinol dehydrogenase 5 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene predicted gene, 25494 Neighboring gene thiol methyltransferase 1B Neighboring gene RIKEN cDNA 9030616G12 gene Neighboring gene olfactory receptor family 10 subfamily P member 22

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Impaired axonal regeneration in alpha7 integrin-deficient mice. Werner A, et al. J Neurosci, 2000 Mar 1. PMID 10684883, Free PMC Article
    2. Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle. Boppart MD, et al. Am J Physiol Regul Integr Comp Physiol, 2008 Nov. PMID 18784336, Free PMC Article
    3. Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression. Liu J, et al. Am J Physiol Cell Physiol, 2008 Feb. PMID 18045857, Free PMC Article
    4. Loss of the alpha7 integrin promotes extracellular signal-regulated kinase activation and altered vascular remodeling. Welser JV, et al. Circ Res, 2007 Sep 28. PMID 17704212
    5. Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injury. Boppart MD, et al. Am J Physiol Cell Physiol, 2006 Jun. PMID 16421207

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse hippocampal neurons.
      Title: Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hippocampal neurons.
    2. Integrin alpha7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
      Title: Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
    3. Association between Decreased ITGA7 Levels and Increased Muscle alpha-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.
      Title: Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.
    4. ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
      Title: ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
    5. Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).
      Title: Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).
    6. miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
      Title: miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
    7. Ptrh2 levels were up-regulated in dystrophin deficient mdx muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx muscle and Duchenne muscular dystrophy patients. Similar to the a7 integrin, Ptrh2 expression was decreased in laminin-a2 null gastrocnemius muscle
      Title: PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.
    8. Deletion of integrin alpha7 subunit does not aggravate the phenotype of laminin alpha2 chain-deficient mice. laminin-211 and integrin alpha7beta1 have intersecting roles in skeletal muscle.
      Title: Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.
    9. Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin and alpha7beta1 integrin.
      Title: Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.
    10. loss of alpha7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice
      Title: Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to laminin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to laminin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin alpha7-beta1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin alpha7-beta1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    integrin alpha-7

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330160.2 → NP_001317089.1  integrin alpha-7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122380
      Consensus CDS
      CCDS88118.1
      UniProtKB/Swiss-Prot
      O88731, O88732, P70350, Q61737, Q61738, Q61741
      UniProtKB/TrEMBL
      Q3TZS3
      Related
      ENSMUSP00000151960.2, ENSMUST00000218290.2
      Conserved Domains (2) summary
      smart00191
      Location:381 → 433
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:475 → 965
      Integrin_alpha2; Integrin alpha

    2. NM_001406285.1 → NP_001393214.1  integrin alpha-7 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122380

    3. NM_001406286.1 → NP_001393215.1  integrin alpha-7 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122380

    4. NM_001406287.1 → NP_001393216.1  integrin alpha-7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122380

    5. NM_008398.3 → NP_032424.2  integrin alpha-7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032424.2

      Status: VALIDATED

      Source sequence(s)
      AC122380
      Consensus CDS
      CCDS24300.1
      UniProtKB/Swiss-Prot
      O88731, O88732, P70350, Q61737, Q61738, Q61741
      UniProtKB/TrEMBL
      G3X9Q1
      Related
      ENSMUSP00000096712.3, ENSMUST00000099112.4
      Conserved Domains (2) summary
      smart00191
      Location:377 → 429
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:471 → 961
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128769633..128794155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244914.2 → XP_030100774.1  integrin alpha-7 isoform X4

      Conserved Domains (2) summary
      smart00191
      Location:214 → 266
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:308 → 798
      Integrin_alpha2; Integrin alpha

    2. XM_006513270.4 → XP_006513333.1  integrin alpha-7 isoform X5

      Conserved Domains (2) summary
      smart00191
      Location:213 → 265
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:307 → 797
      Integrin_alpha2; Integrin alpha

    3. XM_036155649.1 → XP_036011542.1  integrin alpha-7 isoform X6

      Conserved Domains (2) summary
      smart00191
      Location:209 → 261
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:303 → 793
      Integrin_alpha2; Integrin alpha

    4. XM_030244916.2 → XP_030100776.1  integrin alpha-7 isoform X8

      UniProtKB/Swiss-Prot
      O88731, O88732, P70350, Q61737, Q61738, Q61741
      Conserved Domains (2) summary
      smart00191
      Location:377 → 429
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:471 → 961
      Integrin_alpha2; Integrin alpha

    5. XM_030244915.2 → XP_030100775.1  integrin alpha-7 isoform X7

      UniProtKB/Swiss-Prot
      O88731, O88732, P70350, Q61737, Q61738, Q61741
      UniProtKB/TrEMBL
      A0A8V5L190
      Related
      ENSMUSP00000159495.1, ENSMUST00000240553.1
      Conserved Domains (2) summary
      smart00191
      Location:421 → 473
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:515 → 1005
      Integrin_alpha2; Integrin alpha

    6. XM_017313813.3 → XP_017169302.1  integrin alpha-7 isoform X1

      UniProtKB/Swiss-Prot
      O88731, O88732, P70350, Q61737, Q61738, Q61741
      Conserved Domains (2) summary
      smart00191
      Location:381 → 433
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:475 → 965
      Integrin_alpha2; Integrin alpha

    7. XM_006513269.5 → XP_006513332.1  integrin alpha-7 isoform X2

      UniProtKB/Swiss-Prot
      O88731, O88732, P70350, Q61737, Q61738, Q61741
      Conserved Domains (2) summary
      smart00191
      Location:317 → 369
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:411 → 901
      Integrin_alpha2; Integrin alpha

    8. XM_030244913.2 → XP_030100773.1  integrin alpha-7 isoform X3

      UniProtKB/Swiss-Prot
      O88731, O88732, P70350, Q61737, Q61738, Q61741
      Conserved Domains (2) summary
      smart00191
      Location:313 → 365
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:407 → 897
      Integrin_alpha2; Integrin alpha
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61738.3 GenPept UniProtKB/Swiss-Prot:Q61738

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools