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    F11R F11 receptor [ Homo sapiens (human) ]

    Gene ID: 50848, updated on 3-Nov-2024

    Summary

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    Official Symbol
    F11Rprovided by HGNC
    Official Full Name
    F11 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:14685
    See related
    Ensembl:ENSG00000158769 MIM:605721; AllianceGenome:HGNC:14685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
    Summary
    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See F11R in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (160995211..161021152, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160132277..160158230, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160965001..160990942, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904441 Neighboring gene uncharacterized LOC101928372 Neighboring gene intelectin 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:160931121-160931639 Neighboring gene Sharpr-MPRA regulatory region 3396 Neighboring gene Sharpr-MPRA regulatory region 578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160960931-160961769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160975781-160976290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976291-160976800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976801-160977309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160985695-160986292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:160991075-160991672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161002153-161003089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161004943-161005449 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161005450-161005955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1970 Neighboring gene GLR5 pseudogene 2 Neighboring gene thiosulfate sulfurtransferase like domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface. Monteiro AC, et al. Mol Biol Cell, 2014 May. PMID 24672055, Free PMC Article
    2. Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines. Azari BM, et al. J Transl Med, 2011 Jun 26. PMID 21703019, Free PMC Article
    3. Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion. Babinska A, et al. Thromb Haemost, 2002 Apr. PMID 12008956
    4. Low expression of junctional adhesion molecule A is associated with metastasis and poor survival in pancreatic cancer. Fong D, et al. Ann Surg Oncol, 2012 Dec. PMID 22549289
    5. A novel role for junctional adhesion molecule-A in tumor proliferation: modulation by an anti-JAM-A monoclonal antibody. Goetsch L, et al. Int J Cancer, 2013 Mar 15. PMID 22886345

    See all (172) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells.
      Title: JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells.
    2. A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer.
      Title: A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer.
    3. MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer.
      Title: MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer.
    4. Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
      Title: Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
    5. LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
      Title: LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
    6. Association of F11R polymorphisms and gene expression with primary Sjogren's syndrome patients.
      Title: Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients.
    7. Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity.
      Title: Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity.
    8. Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury.
      Title: Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury.
    9. Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
      Title: Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
    10. Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.
      Title: Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.
    Submit: New GeneRIF Correction See all GeneRIFs (102)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of F11R PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cannabinoid inhibits HIV-1 gp120-induced tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in human brain micro vascular endothelial cells (HBMEC) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: TSTD1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of endothelial intestinal barrier IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intestinal absorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in memory T cell extravasation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of platelet aggregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to bicellular tight junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane permeability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction TAS
    Traceable Author Statement
    more info
    		  
    located_in cell-cell junction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in tight junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    junctional adhesion molecule A
    Names
    junctional adhesion molecule 1
    platelet F11 receptor
    platelet adhesion molecule 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348091.2 → NP_001335020.1  junctional adhesion molecule A isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK304412, AL591806
      Consensus CDS
      CCDS86026.1
      UniProtKB/TrEMBL
      Q9Y5B2
      Related
      ENSP00000440812.1, ENST00000537746.1
      Conserved Domains (1) summary
      pfam13927
      Location:78 → 167
      Ig_3; Immunoglobulin domain

    2. NM_001382727.1 → NP_001369656.1  junctional adhesion molecule A isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL591806
      UniProtKB/TrEMBL
      B7Z5W1, E7EPV8
      Conserved Domains (2) summary
      cd20946
      Location:30 → 129
      IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains
      cd20950
      Location:135 → 231
      IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains

    3. NM_001382730.1 → NP_001369659.1  junctional adhesion molecule A isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL591806
      UniProtKB/TrEMBL
      Q9Y5B2
      Conserved Domains (2) summary
      cd20946
      Location:30 → 129
      IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains
      cd20950
      Location:135 → 231
      IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains

    4. NM_001382733.1 → NP_001369662.1  junctional adhesion molecule A isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL591806
      UniProtKB/TrEMBL
      Q9Y5B2
      Conserved Domains (2) summary
      cd20946
      Location:30 → 129
      IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains
      cd20950
      Location:135 → 231
      IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains

    5. NM_001382734.1 → NP_001369663.1  junctional adhesion molecule A isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AL591806
      UniProtKB/TrEMBL
      Q9Y5B2
      Conserved Domains (3) summary
      cd00096
      Location:22 → 30
      Ig; Ig strand B [structural motif]
      cd20950
      Location:112 → 208
      IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
      cl11960
      Location:22 → 106
      Ig; Immunoglobulin domain

    6. NM_016946.6 → NP_058642.1  junctional adhesion molecule A isoform 1 precursor

      See identical proteins and their annotated locations for NP_058642.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF172398, AL591806, DA907460
      Consensus CDS
      CCDS1213.1
      UniProtKB/Swiss-Prot
      B7Z941, Q9Y624
      UniProtKB/TrEMBL
      Q6FIB4, Q9Y5B2
      Related
      ENSP00000357005.5, ENST00000368026.11
      Conserved Domains (2) summary
      smart00410
      Location:36 → 125
      IG_like; Immunoglobulin like
      pfam13927
      Location:135 → 216
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      160995211..161021152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160132277..160158230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144501.1: Suppressed sequence

      Description
      NM_144501.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_144502.1: Suppressed sequence

      Description
      NM_144502.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    3. NM_144503.1: Suppressed sequence

      Description
      NM_144503.1: This RefSeq was permanently suppressed because it is now thought that it represents a rare read-through transcript.

    4. NM_144504.1: Suppressed sequence

      Description
      NM_144504.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y624.1 GenPept UniProtKB/Swiss-Prot:Q9Y624

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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