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    cre cyclization recombinase [ Escherichia phage P1 ]

    Gene ID: 2777477, updated on 3-Apr-2024

    Summary

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    Gene symbol
    cre
    Gene description
    cyclization recombinase
    Locus tag
    P1_gp003
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia phage P1 (isolate: mod749::IS5 c1.100 mutant, nat-host: Escherichia coli)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Punavirus
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    Genomic context

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    Sequence:
    NC_005856.1 (436..1467)

    NC_005856.1Genomic Context describing neighboring genes Neighboring gene cre associated function Neighboring gene C8 Neighboring gene recombination enhancement function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_005856.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synapsis of loxP sites by Cre recombinase. Ghosh K, et al. J Biol Chem, 2007 Aug 17. PMID 17573343
    2. Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse. Wolfe A, et al. J Neuroendocrinol, 2008 Jul. PMID 18445125, Free PMC Article
    3. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. Nagashima K, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28882590
    4. Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality. Zhang J, et al. Clin Exp Pharmacol Physiol, 2012 Feb. PMID 22150821, Free PMC Article
    5. Genome of bacteriophage P1. Łobocka MB, et al. J Bacteriol, 2004 Nov. PMID 15489417, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrates that Col6a1-Cre driver mice are as useful as Twist2-Cre driver mice for functional analyses of GALT-resident mesenchymal cells, including MCi cells.
      Title: Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver.
    2. Cre-recombinase in aP2-Cre mice, showed strong Cre activity in the dorsal hindbrain region and vertebrae of E12.5 embryos.
      Title: Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality.
    3. The GnRH-CRETeR mouse can be used to study genes that may have distinct roles in reproductive physiology during the various developmental stages.
      Title: Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse.
    4. Cre-mediated synapsis of loxP sites occurs with a high affinity and is pH-dependent; the crystal structures of a pre-cleavage Cre-loxP synaptic complex in a configuration representing the starting point in the recombination pathway were determined
      Title: Synapsis of loxP sites by Cre recombinase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    regulatory

    • Loc: 1394-1399 regulatory_class = minus_35_signal
    • Loc: 1394-1425 regulatory_class = promoter , standard_name = Pc8
    • Loc: 1420-1425 regulatory_class = minus_10_signal

    General protein information

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    Preferred Names
    site-specific integrase
    YP_006472.1
    • 24 pct identical to 351 aa integrase-like protein of Pseudomonas sp. in GenBank Accession Number CAA67462; similar to other bacterial integrases-recombinases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_005856.1 Reference assembly

      Range
      436..1467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_006472.1 site-specific integrase [Escherichia phage P1]

      See identical proteins and their annotated locations for YP_006472.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P06956
      UniProtKB/TrEMBL
      A0A385AH54, A0AA96J2R0, B3Y8R6, Q71TG5
      Conserved Domains (1) summary
      cd00799
      Location:153 → 339
      INT_Cre_C; C-terminal catalytic domain of Cre recombinase (also called integrase)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    1NZB_A.1
    1NZB_B.1
    1NZB_E.1
    1NZB_F.1
    1OUQ_A.1
    1OUQ_B.1
    1OUQ_E.1
    1OUQ_F.1
    2CRX_A.1
    2CRX_B.1
    3MGV_A.1
    3MGV_B.1
    3MGV_C.1
    3MGV_D.1
    P06956.1

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