FASN fatty acid synthase [Gallus gallus (chicken)] - Gene

Summary

Symbol: FASNprovided by CGNC
Full Name: fatty acid synthaseprovided by CGNC
Primary source: CGNC:1983
See related: Ensembl:ENSGALG00010029895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	18	NC_052549.1 (5537180..5573293)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	18	NC_052590.1 (5140755..5176894)

Chromosome 18 - NC_052549.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results here can contribute to the knowledge on the developmental expression pattern of FAS mRNA and facilitate the further research on the molecular mechanism underlying intramuscular-fat deposition in chicken
Title: Liver dominant expression of fatty acid synthase (FAS) gene in two chicken breeds during intramuscular-fat development.
Data show that expression of malic enzyme (ME), fatty acid synthase (FAS) and acetyl coenzyme carboxylase (ACC) genes was decreased by feeding a 30% protein diet (acute or chronic feeding).
Title: Further studies on short-term adaptations in the expression of lipogenic genes in broilers.
These data define the chicken FASN gene as a direct target of LXRalpha and further expand the role of LXRalpha as a regulator of lipid metabolism in this species.
Title: Liver X receptor alpha regulates fatty acid synthase expression in chicken.
The effects of the FASN inhibitor cerulenin on food intake adn neuropeptide expression in G. gallus is reported.
Title: FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens.

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General gene information

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Markers

FASNsts4 (e-PCR), detects polymorphism
- UniSTS:279840

FASsts2 (e-PCR), detects polymorphism
- UniSTS:279841

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables fatty acid synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fatty acid synthase

Names: thioesterase

NP_990486.3

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205155.4 → NP_990486.3 fatty acid synthase

Status: VALIDATED

Source sequence(s)

JAENSK010000316

UniProtKB/Swiss-Prot

P12276

Related

ENSGALP00010044781.1, ENSGALT00010072294.1

Conserved Domains (8) summary

cd08954
Location:1854 → 2114

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2113 → 2181

PKS_PP; Phosphopantetheine attachment site

smart00827
Location:496 → 787

PKS_AT; Acyl transferase domain in polyketide synthase (PKS) enzymes

smart00829
Location:1568 → 1858

PKS_ER; Enoylreductase

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

TIGR02072
Location:1237 → 1389

BioC; malonyl-acyl carrier protein O-methyltransferase BioC

cl00509
Location:865 → 1011

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

cl21494
Location:2243 → 2504

Abhydrolase; alpha/beta hydrolases