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    Ltb4r1 leukotriene B4 receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 16995, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Ltb4r1provided by MGI
    Official Full Name
    leukotriene B4 receptor 1provided by MGI
    Primary source
    MGI:MGI:1309472
    See related
    Ensembl:ENSMUSG00000046908 AllianceGenome:MGI:1309472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BLT1; BLTR; Ltb4r; mBLTR; LTB4-R1
    Summary
    Enables leukotriene B4 receptor activity. Acts upstream of or within signal transduction. Predicted to be active in plasma membrane. Is expressed in brain and lateral ventricle. Orthologous to human LTB4R (leukotriene B4 receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 10.3), small intestine adult (RPKM 8.5) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ltb4r1 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56002154..56005951)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55765962..55768492)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Neighboring gene STARR-seq mESC enhancer starr_36778 Neighboring gene leukotriene B4 receptor 2 Neighboring gene adenylate cyclase 4 Neighboring gene predicted gene, 32092 Neighboring gene receptor-interacting serine-threonine kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Critical Role of LTB4/BLT1 in IL-23-Induced Synovial Inflammation and Osteoclastogenesis via NF-κB. Bouchareychas L, et al. J Immunol, 2017 Jan 1. PMID 27895169, Free PMC Article
    2. Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin. Ito S, et al. Shock, 2008 Jul. PMID 18004232
    3. Leukotriene B4 induces release of antimicrobial peptides in lungs of virally infected mice. Gaudreault E, et al. J Immunol, 2008 May 1. PMID 18424743
    4. Leukotriene B4 mediates gammadelta T lymphocyte migration in response to diverse stimuli. Costa MF, et al. J Leukoc Biol, 2010 Feb. PMID 19880577, Free PMC Article
    5. BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis. Zhou J, et al. Cell Mol Immunol, 2018 Dec. PMID 29670278, Free PMC Article

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leukotriene B4 receptor knockdown affects PI3K/AKT/mTOR signaling and apoptotic responses in colorectal cancer.
      Title: Leukotriene B4 receptor knockdown affects PI3K/AKT/mTOR signaling and apoptotic responses in colorectal cancer.
    2. n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
      Title: n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
    3. Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.
      Title: Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.
    4. Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
      Title: Expression of leukotriene B(4) receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
    5. Up-regulating microRNA-138-5p enhances the protective role of dexmedetomidine on myocardial ischemia-reperfusion injury mice via down-regulating Ltb4r1.
      Title: Up-regulating microRNA-138-5p enhances the protective role of dexmedetomidine on myocardial ischemia-reperfusion injury mice via down-regulating Ltb4r1.
    6. Acceleration of Trichinella spiralis worm expulsion by leukotriene B4 receptor binding inhibition.
      Title: Acceleration of Trichinella spiralis worm expulsion by leukotriene B4 receptor binding inhibition.
    7. Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
      Title: Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
    8. Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction.
      Title: Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction.
    9. Leukotriene B4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
      Title: Leukotriene B(4) receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
    10. The LTB4-BLT1 axis regulates actomyosin and beta2-integrin dynamics during neutrophil extravasation.
      Title: The LTB4-BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene B4 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene B4 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables leukotriene receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leukotriene B4 receptor 1
    Names
    LTB4 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411957.1 → NP_001398886.1  leukotriene B4 receptor 1

      Status: VALIDATED

      Source sequence(s)
      AC098877
      UniProtKB/Swiss-Prot
      O88855
      UniProtKB/TrEMBL
      A7VJD3

    2. NM_008519.3 → NP_032545.1  leukotriene B4 receptor 1

      See identical proteins and their annotated locations for NP_032545.1

      Status: VALIDATED

      Source sequence(s)
      AC098877
      Consensus CDS
      CCDS27129.1
      UniProtKB/Swiss-Prot
      O88855
      UniProtKB/TrEMBL
      A7VJD3
      Related
      ENSMUSP00000051368.4, ENSMUST00000057569.4
      Conserved Domains (1) summary
      pfam00001
      Location:37 → 285
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56002154..56005951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88855.1 GenPept UniProtKB/Swiss-Prot:O88855

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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