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Envelope surface glycoprotein gp120
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env
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HIV-1 gp120 upregulates the expression of jun proto-oncogene (JUN, AP-1) in human B cells |
PubMed
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env
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HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites |
PubMed
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env
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The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 |
PubMed
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env
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HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun |
PubMed
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env
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Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway |
PubMed
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env
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HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation |
PubMed
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env
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Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus |
PubMed
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Envelope surface glycoprotein gp160, precursor
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env
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HIV-1 gp160 induces activation of transcription factor, activated protein-1 (AP-1), comprised of Fos and Jun proteins, in CD4 positive T cell lines |
PubMed
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Nef
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nef
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HIV-1 Nef treatment [of SVGA cells] increases phosphorylation of JUN (c-Jun) in SVGA cells |
PubMed
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nef
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HIV-1 Nef-mediated increase in IL6 expression is enhanced by JUN (AP-1) |
PubMed
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nef
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Knockdown of C/EBPalpha, C/EBPgamma, and AP-1 by siRNA shows significant reduction of CCL5 levels, suggesting that C/EBPalpha, C/EBPgamma, and AP-1 proteins are involved in Nef-mediated upregulation of CCL5 |
PubMed
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nef
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HIV-1 Nef expression in human (THP-1) monocyte-macrophages induces both DNA binding and transcriptional activities of the activator protein-1 (AP-1) transcription factor, c-fos and c-jun; this induction requires the proline-rich PxxP motif of Nef |
PubMed
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nef
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HIV-1 Nef inhibits c-jun transcription in mitogen-stimulated human T cells |
PubMed
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Tat
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tat
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c-JUN enhances HIV-1 Tat-mediated LTR transcription but suppresses basal LTR transcription in the absence of Tat |
PubMed
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tat
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HIV-1 Tat induces JUN (AP1) DNA binding activity in CRT-MG cells (as assessed by EMSA) and this activity is enhanced by HDAC6 |
PubMed
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tat
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HIV-1 Tat induces phosphorylation of JUN (AP1) in CRT-MG human astroglioma cells |
PubMed
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tat
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HIV-1 Tat activates AP-1 (c-Jun/c-Fos) activity in human astroglioma cells |
PubMed
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tat
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HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins |
PubMed
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tat
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Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2 |
PubMed
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tat
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Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells |
PubMed
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tat
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HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR |
PubMed
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tat
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The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) blocks HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppress HIV-1 provirus transcription |
PubMed
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tat
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HIV-1 Tat interacts with the cooperative rel/AP1 complex, downregulating its transactivation activity and leading to a decrease in IL-2 gene transcription |
PubMed
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tat
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HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck |
PubMed
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tat
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Crosslinking experiments suggest a direct binding interaction between HIV-1 Tat and AP1 that is relatively inefficient and that correlates with the ability of AP1 to support Tat transactivation |
PubMed
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tat
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HIV-1 Tat-induced expression of MCP-1 is partially mediated through the activation of c-jun (Activator Protein-1; AP-1) binding to, and transactivation of the MCP-1 promoter by Tat |
PubMed
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Vpr
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vpr
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HIV-1 Vpr involves the JUN (AP-1) transcription factor in the induction of CXCL8 (IL8) in astrocytes |
PubMed
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vpr
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HIV-1 Vpr involves the JUN (AP-1) transcription factor in the induction of IL6 in astrocytes |
PubMed
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vpr
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HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes |
PubMed
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vpr
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Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages. |
PubMed
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Vpu
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vpu
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HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor |
PubMed
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