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    GNAS GNAS complex locus [ Canis lupus familiaris (dog) ]

    Gene ID: 403943, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GNASprovided by VGNC
    Official Full Name
    GNAS complex locusprovided by VGNC
    Primary source
    VGNC:VGNC:54650
    See related
    Ensembl:ENSCAFG00845013733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    gnas1
    Orthologs
    human mouse all
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    Genomic context

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    See GNAS in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (44469667..44524884)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (42885440..42905085)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (44387669..44407318)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (43609062..43628699)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (43727472..43747093)

    Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene aminopeptidase like 1 Neighboring gene uncharacterized LOC102153173 Neighboring gene uncharacterized LOC119865708 Neighboring gene phosphorylated adapter RNA export protein-like Neighboring gene negative elongation factor complex member C/D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs. Yu Y, et al. BMC Genomics, 2022 Sep 23. PMID 36151521, Free PMC Article
    2. Exclusion of a T>C sequence variant in exon 7 of the canine G(alphas) gene (GNAS1) as a causal gene for liver cancer. Dudenbostel KJ, et al. Anim Genet, 2009 Oct. PMID 19422361
    3. Alternative promoter and 5' exon generate a novel Gs alpha mRNA. Ishikawa Y, et al. J Biol Chem, 1990 May 25. PMID 2111318
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs.
      Title: A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs.
    2. Exclusion of a T>C sequence variant in exon 7 of the canine G(alphas) gene (GNAS1) as a causal gene for liver cancer.
      Title: Exclusion of a T>C sequence variant in exon 7 of the canine G(alphas) gene (GNAS1) as a causal gene for liver cancer.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-2 adrenergic receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotropin-releasing hormone receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin-like growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mu-type opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(s) subunit alpha
    Names
    GTP-binding regulatory protein alpha subunit exon 1
    adenylate cyclase-stimulating G alpha protein
    guanine nucleotide binding protein alpha subunit
    guanine nucleotide binding protein, alpha stimulating activity polypeptide 1
    stimulatory GTP binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003263.1 → NP_001003263.1  guanine nucleotide-binding protein G(s) subunit alpha

      See identical proteins and their annotated locations for NP_001003263.1

      Status: PROVISIONAL

      Source sequence(s)
      Z12168
      UniProtKB/Swiss-Prot
      P63091
      UniProtKB/TrEMBL
      A0A8C0LD06, A0A8C0P585, A0A8I3NFU9
      Related
      ENSCAFP00845019485.1, ENSCAFT00845024770.1
      Conserved Domains (1) summary
      cd00066
      Location:41 → 388
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051828.1 Reference ROS_Cfam_1.0

      Range
      44469667..44524884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038432802.1 → XP_038288730.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8P0TNP4
      Conserved Domains (3) summary
      cd00066
      Location:629 → 961
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      PHA03247
      Location:29 → 386
      PHA03247; large tegument protein UL36; Provisional
      cd22249
      Location:587 → 621
      UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins

    2. XM_038432801.1 → XP_038288729.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0NMX5, A0A8I3NR61, A0A8P0TNP4
      Related
      ENSCAFP00845019414.1, ENSCAFT00845024669.1
      Conserved Domains (3) summary
      cd00066
      Location:629 → 976
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      PHA03247
      Location:29 → 386
      PHA03247; large tegument protein UL36; Provisional
      cd22249
      Location:587 → 621
      UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins

    3. XM_038432808.1 → XP_038288736.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X8

      UniProtKB/TrEMBL
      A0A8C0P585, A0A8I3NFU9
      Conserved Domains (1) summary
      cd00066
      Location:1 → 329
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    4. XM_038432807.1 → XP_038288735.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X7

      UniProtKB/TrEMBL
      A0A8C0P585, A0A8I3NFU9
      Conserved Domains (1) summary
      cd00066
      Location:1 → 330
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    5. XM_038432803.1 → XP_038288731.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8C0P585, A0A8I3NFU9
      Conserved Domains (1) summary
      cd00066
      Location:41 → 389
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    6. XM_038432804.1 → XP_038288732.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0P585, A0A8I3NFU9
      Conserved Domains (1) summary
      cd00066
      Location:41 → 374
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    7. XM_038432805.1 → XP_038288733.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X5

      UniProtKB/TrEMBL
      A0A8C0P585, A0A8I3NFU9
      Conserved Domains (1) summary
      cd00066
      Location:41 → 373
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    8. XM_038432806.1 → XP_038288734.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X6

      UniProtKB/TrEMBL
      A0A8C0P585, A0A8I3NFU9
      Related
      ENSCAFP00845019386.1, ENSCAFT00845024641.1
      Conserved Domains (1) summary
      cd00066
      Location:8 → 349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049284.1 Alternate UMICH_Zoey_3.1

      Range
      43609062..43628699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

      Range
      43727472..43747093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

      Range
      44387669..44407318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      42885440..42905085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63091.1 GenPept UniProtKB/Swiss-Prot:P63091

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    Research Materials