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    FOLR2 folate receptor beta [ Homo sapiens (human) ]

    Gene ID: 2350, updated on 3-Apr-2024

    Summary

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    Official Symbol
    FOLR2provided by HGNC
    Official Full Name
    folate receptor betaprovided by HGNC
    Primary source
    HGNC:HGNC:3793
    See related
    Ensembl:ENSG00000165457 MIM:136425; AllianceGenome:HGNC:3793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1
    Summary
    The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 67.9), gall bladder (RPKM 33.0) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q13.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72216794..72221950)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72143410..72148566)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71927838..71932994)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene folate receptor 3 pseudogene 1 Neighboring gene folate receptor alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3717 Neighboring gene skeletal muscle cis-regulatory module in INPPL1 intron Neighboring gene inositol polyphosphate phosphatase like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3718 Neighboring gene paired like homeobox 2A Neighboring gene dedicator of cytokinesis 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis. . Cancer Discov, 2022 Jun 2. PMID 35394484
    2. Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids. Warmink K, et al. Cartilage, 2022 Jan-Mar. PMID 35255727, Free PMC Article
    3. Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis. Steinz MM, et al. Front Immunol, 2022. PMID 35185910, Free PMC Article
    4. Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes. Lu YJ, et al. Cell Rep Med, 2021 Oct 19. PMID 34755134, Free PMC Article
    5. Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy. Roy AG, et al. Int J Mol Sci, 2021 May 25. PMID 34070369, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.
      Title: microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.
    2. Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.
      Title: Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.
    3. FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis.
      Title: FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis.
    4. Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.", trans "FOLR1FOLR2.
      Title: Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.
    5. Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.
      Title: Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.
    6. Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.
      Title: Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.
    7. Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes.
      Title: Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes.
    8. Targeting folate receptor beta positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex.
      Title: Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex.
    9. Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy.
      Title: Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy.
    10. Folate Receptor beta (FRbeta) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.
      Title: Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of folate receptor 2 (FOLR2) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables folic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables folic acid receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables folic acid receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to folic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm-egg recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    folate receptor beta
    Names
    folate receptor 2 (fetal)
    folate receptor alpha
    folate receptor, fetal/placental
    folate-binding protein, fetal/placental
    placental folate-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000803.5 → NP_000794.3  folate receptor beta precursor

      See identical proteins and their annotated locations for NP_000794.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
      Source sequence(s)
      AK222643, CD014063
      Consensus CDS
      CCDS8212.1
      UniProtKB/Swiss-Prot
      P14207, Q05CA5, Q6GTE8
      UniProtKB/TrEMBL
      Q53HP1
      Related
      ENSP00000298223.6, ENST00000298223.11
      Conserved Domains (1) summary
      pfam03024
      Location:30 → 205
      Folate_rec; Folate receptor family

    2. NM_001113534.2 → NP_001107006.1  folate receptor beta precursor

      See identical proteins and their annotated locations for NP_001107006.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      BM849995, CD014063, CD692073
      Consensus CDS
      CCDS8212.1
      UniProtKB/Swiss-Prot
      P14207, Q05CA5, Q6GTE8
      UniProtKB/TrEMBL
      Q53HP1
      Conserved Domains (1) summary
      pfam03024
      Location:30 → 205
      Folate_rec; Folate receptor family

    3. NM_001113535.2 → NP_001107007.1  folate receptor beta precursor

      See identical proteins and their annotated locations for NP_001107007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      BM691283, BM849995, CD014063
      Consensus CDS
      CCDS8212.1
      UniProtKB/Swiss-Prot
      P14207, Q05CA5, Q6GTE8
      UniProtKB/TrEMBL
      Q53HP1
      Conserved Domains (1) summary
      pfam03024
      Location:30 → 205
      Folate_rec; Folate receptor family

    4. NM_001113536.2 → NP_001107008.1  folate receptor beta precursor

      See identical proteins and their annotated locations for NP_001107008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      BY797003, CD014063
      Consensus CDS
      CCDS8212.1
      UniProtKB/Swiss-Prot
      P14207, Q05CA5, Q6GTE8
      UniProtKB/TrEMBL
      Q53HP1
      Conserved Domains (1) summary
      pfam03024
      Location:30 → 205
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      72216794..72221950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426683.1 → XP_047282639.1  folate receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P14207, Q05CA5, Q6GTE8

    2. XM_005273856.5 → XP_005273913.1  folate receptor beta isoform X1

      UniProtKB/TrEMBL
      Q53HP1
      Conserved Domains (1) summary
      pfam03024
      Location:39 → 214
      Folate_rec; Folate receptor family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      72143410..72148566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368249.1 → XP_054224224.1  folate receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P14207, Q05CA5, Q6GTE8

    2. XM_054368248.1 → XP_054224223.1  folate receptor beta isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14207.4 GenPept UniProtKB/Swiss-Prot:P14207

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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