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    fgfr2.L fibroblast growth factor receptor 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399325, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fgfr2.L
    Official Full Name
    fibroblast growth factor receptor 2 L homeolog
    Primary source
    Xenbase:XB-GENE-1018301
    Locus tag
    XELAEV_18034531mg
    See related
    EnsemblRapid:ENSXLAG00005011276
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    fgfr2; xfgfr2
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    Genomic context

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    See fgfr2.L in Genome Data Viewer
    Location:
    chromosome: 7L
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (13829236..13901293)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (13872526..13944728)

    Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component L homeolog Neighboring gene arginyltransferase 1 L homeolog Neighboring gene WD repeat domain 11 L homeolog Neighboring gene phospholipid phosphatase 4 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development. Friesel R, et al. Development, 1992 Dec. PMID 1284237
    2. Identification of Sef, a novel modulator of FGF signalling. Tsang M, et al. Nat Cell Biol, 2002 Feb. PMID 11802164
    3. Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2. Mathieu M, et al. J Biol Chem, 1995 Mar 24. PMID 7896824
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 2
    Names
    FGFR-2
    fibroblast growth factor receptor 2b
    fibroblast growth factor receptor-2
    NP_001084132.1
    XP_018079903.1
    XP_018079904.1
    XP_018079905.1
    XP_018079906.1
    XP_018079907.1
    XP_041424381.1
    XP_041424382.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090663.1 → NP_001084132.1  fibroblast growth factor receptor 2 precursor

      See identical proteins and their annotated locations for NP_001084132.1

      Status: PROVISIONAL

      Source sequence(s)
      BC073456
      UniProtKB/Swiss-Prot
      Q03364
      UniProtKB/TrEMBL
      Q6GNP8
      Related
      ENSXLAP00005033153.1, ENSXLAT00005033947.1
      Conserved Domains (7) summary
      cd05857
      Location:155 → 239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:262 → 351
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00409
      Location:165 → 239
      IG; Immunoglobulin
      smart00410
      Location:254 → 350
      IG_like; Immunoglobulin like
      cd05101
      Location:447 → 759
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam07714
      Location:472 → 748
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:44 → 116
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      13829236..13901293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018224415.2 → XP_018079904.1  fibroblast growth factor receptor 2 isoform X2

      UniProtKB/Swiss-Prot
      Q03364
      UniProtKB/TrEMBL
      A0A8J0T8A9
      Related
      ENSXLAP00005033163.1, ENSXLAT00005033957.1

    2. XM_041568448.1 → XP_041424382.1  fibroblast growth factor receptor 2 isoform X7

      UniProtKB/TrEMBL
      A0A679F0V0, A0A8J1L4A8
      Conserved Domains (4) summary
      smart00408
      Location:99 → 164
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:189 → 283
      IG; Immunoglobulin
      cd05101
      Location:382 → 694
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      cd00096
      Location:114 → 118
      Ig; Ig strand C [structural motif]

    3. XM_018224414.2 → XP_018079903.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q03364
      UniProtKB/TrEMBL
      A0A8J0T8A2

    4. XM_018224416.2 → XP_018079905.1  fibroblast growth factor receptor 2 isoform X3

      UniProtKB/Swiss-Prot
      Q03364
      UniProtKB/TrEMBL
      A0A8J0T980
      Related
      ENSXLAP00005033166.1, ENSXLAT00005033960.1

    5. XM_041568447.1 → XP_041424381.1  fibroblast growth factor receptor 2 isoform X5

      UniProtKB/Swiss-Prot
      Q03364
      UniProtKB/TrEMBL
      A0A8J1L4A7
      Conserved Domains (4) summary
      smart00408
      Location:184 → 249
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:274 → 368
      IG_like; Immunoglobulin like
      cd05101
      Location:467 → 779
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      cd00096
      Location:199 → 203
      Ig; Ig strand C [structural motif]

    6. XM_018224417.2 → XP_018079906.1  fibroblast growth factor receptor 2 isoform X4

      UniProtKB/Swiss-Prot
      Q03364
      UniProtKB/TrEMBL
      A0A8J0T634

    7. XM_018224418.2 → XP_018079907.1  fibroblast growth factor receptor 2 isoform X6

      UniProtKB/Swiss-Prot
      Q03364
      UniProtKB/TrEMBL
      A0A1L8FJ12, A0A974HBB3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03364.1 GenPept UniProtKB/Swiss-Prot:Q03364

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