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    SLC12A3 solute carrier family 12 member 3 [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102146157, updated on 10-Oct-2024

    Summary

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    Gene symbol
    SLC12A3
    Gene description
    solute carrier family 12 member 3
    See related
    Ensembl:ENSMFAG00000045325
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SLC12A3 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 20 NC_088394.1 (52970990..53036014)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 20 NC_052274.1 (43840910..43890966)

    Chromosome 20 - NC_088394.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC135968848 Neighboring gene nucleoporin 93 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene small nucleolar RNA U3 Neighboring gene homocysteine inducible ER protein with ubiquitin like domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables sodium:potassium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 12 member 3
    Names
    Thiazide-sensitive sodium-chloride cotransporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088394.1 Reference T2T-MFA8v1.0

      Range
      52970990..53036014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_065537092.1 → XP_065393164.1  solute carrier family 12 member 3 isoform X10

    2. XM_065537093.1 → XP_065393165.1  solute carrier family 12 member 3 isoform X12

    3. XM_005591998.4 → XP_005592055.3  solute carrier family 12 member 3 isoform X6

    4. XM_005591996.4 → XP_005592053.1  solute carrier family 12 member 3 isoform X4

      See identical proteins and their annotated locations for XP_005592053.1

      UniProtKB/TrEMBL
      A0A2K5VSS9, A0A7N9CYY2, A0A8J8XK92, G7Q167
      Related
      ENSMFAP00000027891.1
      Conserved Domains (3) summary
      TIGR00930
      Location:59 → 1029
      2a30; K-Cl cotransporter
      pfam03522
      Location:655 → 1029
      SLC12; Solute carrier family 12
      pfam08403
      Location:45 → 115
      AA_permease_N; Amino acid permease N-terminal

    5. XM_005591999.4 → XP_005592056.1  solute carrier family 12 member 3 isoform X8

      UniProtKB/TrEMBL
      A0A7N9CYY2
      Conserved Domains (3) summary
      TIGR00930
      Location:59 → 1020
      2a30; K-Cl cotransporter
      pfam03522
      Location:655 → 1020
      SLC12; Solute carrier family 12
      pfam08403
      Location:45 → 115
      AA_permease_N; Amino acid permease N-terminal

    6. XM_005591997.4 → XP_005592054.1  solute carrier family 12 member 3 isoform X5

      UniProtKB/TrEMBL
      A0A7N9CYY2
      Conserved Domains (3) summary
      TIGR00930
      Location:59 → 1028
      2a30; K-Cl cotransporter
      pfam03522
      Location:654 → 1028
      SLC12; Solute carrier family 12
      pfam08403
      Location:45 → 114
      AA_permease_N; Amino acid permease N-terminal

    7. XM_005592000.4 → XP_005592057.1  solute carrier family 12 member 3 isoform X9

      UniProtKB/TrEMBL
      A0A7N9CYY2
      Conserved Domains (3) summary
      TIGR00930
      Location:59 → 1019
      2a30; K-Cl cotransporter
      pfam03522
      Location:654 → 1019
      SLC12; Solute carrier family 12
      pfam08403
      Location:45 → 114
      AA_permease_N; Amino acid permease N-terminal

    8. XM_015443220.3 → XP_015298706.3  solute carrier family 12 member 3 isoform X1

    9. XM_015443222.3 → XP_015298708.3  solute carrier family 12 member 3 isoform X3

    10. XM_015443224.3 → XP_015298710.3  solute carrier family 12 member 3 isoform X7

    11. XM_045381862.2 → XP_045237797.2  solute carrier family 12 member 3 isoform X11

    12. XM_045381864.2 → XP_045237799.2  solute carrier family 12 member 3 isoform X14

    13. XM_015443221.3 → XP_015298707.3  solute carrier family 12 member 3 isoform X2

    14. XM_045381863.2 → XP_045237798.1  solute carrier family 12 member 3 isoform X13

    15. XM_065537094.1 → XP_065393166.1  solute carrier family 12 member 3 isoform X15

    16. XM_065537095.1 → XP_065393167.1  solute carrier family 12 member 3 isoform X16

    17. XM_065537096.1 → XP_065393168.1  solute carrier family 12 member 3 isoform X17

    RNA

    1. XR_286989.4 RNA Sequence

    2. XR_006694691.2 RNA Sequence

    3. XR_010583810.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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