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    NPC2 NPC intracellular cholesterol transporter 2 [ Bos mutus (wild yak) ]

    Gene ID: 102271732, updated on 10-Mar-2024

    Summary

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    Gene symbol
    NPC2
    Gene description
    NPC intracellular cholesterol transporter 2
    Locus tag
    M91_20337
    See related
    Ensembl:ENSBMUG00000007338
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos mutus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NPC2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    101 current BosGru_v2.0 (GCF_000298355.1) Unplaced Scaffold NW_005394281.1 (204725..213411, complement)

    NW_005394281.1Genomic Context describing neighboring genes Neighboring gene vertebrae development associated Neighboring gene synapse differentiation inducing 1 like Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene latent transforming growth factor beta binding protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_005394281.1 Unplaced Scaffold Reference BosGru_v2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol efflux IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epididymal secretory protein E1
    Names
    Epididymal secretory protein E1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Bos mutus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference BosGru_v2.0 Primary Assembly

    Genomic

    1. NW_005394281.1 Reference BosGru_v2.0 Primary Assembly

      Range
      204725..213411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005900977.2 → XP_005901039.1  epididymal secretory protein E1

      See identical proteins and their annotated locations for XP_005901039.1

      UniProtKB/TrEMBL
      A0A6B0RPM4, L8I8T2
      Related
      ENSBMUP00000009429.1, ENSBMUT00000010974.1
      Conserved Domains (1) summary
      cd00916
      Location:24 → 145
      Npc2_like; Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived ...
    Nucleotide Protein
    Heading Accession and Version

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