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    TEKT4 tektin 4 [ Homo sapiens (human) ]

    Gene ID: 150483, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TEKT4provided by HGNC
    Official Full Name
    tektin 4provided by HGNC
    Primary source
    HGNC:HGNC:31012
    See related
    Ensembl:ENSG00000163060 AllianceGenome:HGNC:31012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in cilium assembly and flagellated sperm motility. Predicted to act upstream of with a positive effect on regulation of brood size. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.6) and 1 other tissue See more
    Orthologs
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    Genomic context

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    See TEKT4 in Genome Data Viewer
    Location:
    2q11.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (94871430..94876823)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95377957..95383351)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95537175..95542568)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 20 family member A8, pseudogene Neighboring gene RNA, U6 small nuclear 1320, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95535972-95536485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:95536999-95537512 Neighboring gene SOWAHC pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:95539413-95540274 Neighboring gene uncharacterized LOC442028 Neighboring gene MT-CO1 pseudogene 48 Neighboring gene MT-CO3 pseudogene 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Expression of TEKT4 protein decreases in the ejaculated spermatozoa of idiopathic asthenozoospermic men]. Wu WB, et al. Zhonghua Nan Ke Xue, 2012 Jun. PMID 22774605
    2. Enriched variations in TEKT4 and breast cancer resistance to paclitaxel. Jiang YZ, et al. Nat Commun, 2014 May 13. PMID 24823476
    3. TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway. Zheng Z, et al. Endocr Pathol, 2018 Dec. PMID 30251060
    4. Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor. Ge LP, et al. Oncogene, 2021 Mar. PMID 33654196
    5. SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Gui M, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191189, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
      Title: Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
    2. Our study revealed that TEKT4 shows important biological implications in papillary thyroid cancer
      Title: TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway.
    3. TEKT4 germline variations in a high cis linkage are biologically relevant, as ectopic expression of variant TEKT4 deregulates microtubule stability, antagonizes paclitaxel-induced stabilizing effect of microtubules and increases paclitaxel resistance.
      Title: Enriched variations in TEKT4 and breast cancer resistance to paclitaxel.
    4. The expression of TEKT4 is significantly decreased in the ejaculated sperm of idiopathic asthenozoospermia patients.
      Title: [Expression of TEKT4 protein decreases in the ejaculated spermatozoa of idiopathic asthenozoospermic men].
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC27019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tektin-4
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286559.2 → NP_001273488.1  tektin-4 isoform 2

      See identical proteins and their annotated locations for NP_001273488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC097374, AK097438
      Related
      ENST00000468063.1
      Conserved Domains (1) summary
      pfam03148
      Location:2 → 241
      Tektin; Tektin family

    2. NM_144705.4 → NP_653306.1  tektin-4 isoform 1

      See identical proteins and their annotated locations for NP_653306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC097374, BC021716, BI832036
      Consensus CDS
      CCDS2005.1
      UniProtKB/Swiss-Prot
      Q8WW24
      UniProtKB/TrEMBL
      A0A384MEB7
      Related
      ENSP00000295201.4, ENST00000295201.5
      Conserved Domains (1) summary
      pfam03148
      Location:44 → 423
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      94871430..94876823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510670.3 → XP_011508972.1  tektin-4 isoform X1

      Conserved Domains (1) summary
      pfam03148
      Location:44 → 464
      Tektin; Tektin family

    2. XM_005263876.4 → XP_005263933.1  tektin-4 isoform X2

      Conserved Domains (1) summary
      pfam03148
      Location:44 → 312
      Tektin; Tektin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      95377957..95383351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340654.1 → XP_054196629.1  tektin-4 isoform X1

    2. XM_054340655.1 → XP_054196630.1  tektin-4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WW24.1 GenPept UniProtKB/Swiss-Prot:Q8WW24

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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