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    Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362228, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Naa20provided by RGD
    Official Full Name
    N(alpha)-acetyltransferase 20, NatB catalytic subunitprovided by RGD
    Primary source
    RGD:1307713
    See related
    EnsemblRapid:ENSRNOG00000010523 AllianceGenome:RGD:1307713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nat5
    Summary
    Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation and regulation of actin cytoskeleton organization. Predicted to be located in cytosol and nucleus. Predicted to be part of NatB complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 73. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 262.6), Heart (RPKM 256.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naa20 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (153775351..153790129)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (133322036..133336843)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (140106723..140125047)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 2 Neighboring gene probable rRNA-processing protein EBP2 pseudogene Neighboring gene transfer RNA threonine (anticodon AGU) 15 Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene cilia and flagella associated protein 61 Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 3 Neighboring gene INSM transcriptional repressor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. Aksnes H, et al. Cell Rep, 2015 Mar 3. PMID 25732826
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-aspartic acid acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-terminal peptidyl-aspartic acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-glutamic acid acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-terminal peptidyl-glutamic acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-glutamine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-terminal peptidyl-glutamine acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 20
    Names
    N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)
    NP_001102065.1
    XP_006235217.1
    XP_063140240.1
    XP_063140241.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108595.2 → NP_001102065.1  N-alpha-acetyltransferase 20 isoform a

      See identical proteins and their annotated locations for NP_001102065.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6K778, B2RZ44, F7FBG0
      Conserved Domains (1) summary
      COG0456
      Location:1 → 166
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    2. NM_001434355.1 → NP_001421284.1  N-alpha-acetyltransferase 20 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001434356.1 → NP_001421285.1  N-alpha-acetyltransferase 20 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_001434357.1 → NP_001421286.1  N-alpha-acetyltransferase 20 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001434358.1 → NP_001421287.1  N-alpha-acetyltransferase 20 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      153775351..153790129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235155.5 → XP_006235217.1  N-alpha-acetyltransferase 20 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUK2, A6K778, A6K780
      Related
      ENSRNOP00000014047.5, ENSRNOT00000014046.8
      Conserved Domains (1) summary
      COG0456
      Location:1 → 156
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    2. XM_063284170.1 → XP_063140240.1  N-alpha-acetyltransferase 20 isoform X2

    3. XM_063284171.1 → XP_063140241.1  N-alpha-acetyltransferase 20 isoform X3

      Related
      ENSRNOP00000097128.2, ENSRNOT00000107065.2
    Nucleotide Protein Strain
    Heading Accession and Version

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