U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Atp6v1h ATPase H+ transporting V1 subunit H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297797, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Atp6v1hprovided by RGD
    Official Full Name
    ATPase H+ transporting V1 subunit Hprovided by RGD
    Primary source
    RGD:1562450
    See related
    EnsemblRapid:ENSRNOG00000030862 AllianceGenome:RGD:1562450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SFD; VMA13; CGI-11; SFDbeta; SFDalpha
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in endocytosis and synaptic vesicle lumen acidification. Is extrinsic component of synaptic vesicle membrane. Orthologous to human ATP6V1H (ATPase H+ transporting V1 subunit H). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 419.0), Kidney (RPKM 330.1) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Atp6v1h in Genome Data Viewer
    Location:
    5q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (19176849..19282516, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (14379029..14484703, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (14262352..14367898, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein, pseudogene 2 Neighboring gene uncharacterized LOC108350923 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 36 Neighboring gene regulator of G-protein signaling 20 Neighboring gene transcription elongation factor A1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. Geyer M, et al. J Biol Chem, 2002 Aug 9. PMID 12032142
    2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, et al. Neuron, 2013 Apr 24. PMID 23622064
    3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extrinsic component of synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    V-type proton ATPase subunit H
    Names
    ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
    ATPase, H+ transporting, lysosomal V1 subunit H
    V-ATPase H subunit
    vacuolar ATP synthase subunit H
    vacuolar ATPase subunit H
    vacuolar proton pump H subunit
    NP_001013951.1
    NP_001385914.1
    NP_001385915.1
    XP_006237864.1
    XP_006237866.1
    XP_008761746.1
    XP_063143342.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013929.1 → NP_001013951.1  V-type proton ATPase subunit H isoform 2

      See identical proteins and their annotated locations for NP_001013951.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083669
      UniProtKB/TrEMBL
      E9PTI1, Q5XIL1
      Related
      ENSRNOP00000059400.1, ENSRNOT00000065402.3
      Conserved Domains (1) summary
      cd00256
      Location:17 → 423
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...

    2. NM_001398985.1 → NP_001385914.1  V-type proton ATPase subunit H isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZQ24, A6JFI5
      Related
      ENSRNOP00000075016.3, ENSRNOT00000085654.3
      Conserved Domains (1) summary
      cd00256
      Location:17 → 465
      VATPase_H; regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is ...

    3. NM_001398986.1 → NP_001385915.1  V-type proton ATPase subunit H isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000089383.2, ENSRNOT00000119212.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      19176849..19282516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237802.4 → XP_006237864.1  V-type proton ATPase subunit H isoform X1

      See identical proteins and their annotated locations for XP_006237864.1

      UniProtKB/TrEMBL
      A0A8I5ZQ24, A0A8I5ZWI2, A6JFI5
      Conserved Domains (1) summary
      cd00256
      Location:17 → 465
      VATPase_H; regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is ...

    2. XM_063287272.1 → XP_063143342.1  V-type proton ATPase subunit H isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACJ2

    3. XM_006237804.4 → XP_006237866.1  V-type proton ATPase subunit H isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWI2, A0A8I6ACJ2
      Conserved Domains (1) summary
      cd00256
      Location:17 → 447
      VATPase_H; regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is ...

    4. XM_008763524.3 → XP_008761746.1  V-type proton ATPase subunit H isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIG1
      Conserved Domains (1) summary
      cd00256
      Location:1 → 425
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools