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    Abat 4-aminobutyrate aminotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81632, updated on 28-Oct-2024

    Summary

    Official Symbol
    Abatprovided by RGD
    Official Full Name
    4-aminobutyrate aminotransferaseprovided by RGD
    Primary source
    RGD:620948
    See related
    EnsemblRapid:ENSRNOG00000002636 AllianceGenome:RGD:620948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gabat; beta-AlaAT
    Summary
    Enables 4-aminobutyrate:2-oxoglutarate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Located in mitochondrial matrix. Used to study several diseases, including Huntington's disease; depressive disorder; epilepsy (multiple); heroin dependence; and ischemia. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Liver (RPKM 378.6), Kidney (RPKM 369.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Abat in Genome Data Viewer
    Location:
    10q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (7503351..7599474, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (6996688..7092835, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (7093406..7200439, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphomannomutase 2 Neighboring gene transmembrane protein 186 Neighboring gene uncharacterized LOC120095023 Neighboring gene uncharacterized LOC134480750 Neighboring gene methyltransferase 22, Kin17 lysine

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93392

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (S)-3-amino-2-methylpropionate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables succinate-semialdehyde dehydrogenase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables succinate-semialdehyde dehydrogenase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to cocaine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in copulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gamma-aminobutyric acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gamma-aminobutyric acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gamma-aminobutyric acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-aminobutyric acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gamma-aminobutyric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of aspartate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of heat generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of prolactin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of uterine smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to iron ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of 4-aminobutyrate transaminase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of 4-aminobutyrate transaminase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    4-aminobutyrate aminotransferase, mitochondrial
    Names
    (S)-3-amino-2-methylpropionate transaminase
    GABA aminotransferase
    GABA transaminase
    GABA-AT
    GABA-T
    L-AIBAT
    beta-AlaAT I
    gamma-amino-N-butyrate transaminase
    NP_112265.1
    XP_006245822.1
    XP_063126013.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031003.2NP_112265.1  4-aminobutyrate aminotransferase, mitochondrial

      See identical proteins and their annotated locations for NP_112265.1

      Status: PROVISIONAL

      Source sequence(s)
      D87839
      UniProtKB/TrEMBL
      A0A8I6G7C5
      Related
      ENSRNOP00000003633.2, ENSRNOT00000003633.6
      Conserved Domains (2) summary
      TIGR00699
      Location:34496
      GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
      COG0160
      Location:42498
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      7503351..7599474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245760.5XP_006245822.1  4-aminobutyrate aminotransferase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006245822.1

      UniProtKB/Swiss-Prot
      O70539, P50554, Q66HM1
      UniProtKB/TrEMBL
      A0A8I6G7C5, A6K4M1
      Conserved Domains (2) summary
      TIGR00699
      Location:34496
      GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
      COG0160
      Location:42498
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
    2. XM_063269943.1XP_063126013.1  4-aminobutyrate aminotransferase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      O70539, P50554, Q66HM1
      UniProtKB/TrEMBL
      A6K4M1