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    Prpsap2 phosphoribosyl pyrophosphate synthetase-associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117272, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prpsap2provided by RGD
    Official Full Name
    phosphoribosyl pyrophosphate synthetase-associated protein 2provided by RGD
    Primary source
    RGD:620207
    See related
    EnsemblRapid:ENSRNOG00000002724 AllianceGenome:RGD:620207
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pap41
    Summary
    Predicted to enable enzyme regulator activity and identical protein binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to act upstream of or within bone development. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 172.2), Thymus (RPKM 169.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prpsap2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46910282..46945401, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46410817..46445929, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48008799..48044435, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480802 Neighboring gene GRB2-related adaptor protein Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene A-kinase anchoring protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein. Sonoda T, et al. Biochim Biophys Acta, 1997 Jan 3. PMID 9003449
    2. Rat liver phosphoribosyl pyrophosphate synthetase: existence of the purified enzyme as heterogeneous aggregates and identification of the catalytic subunit. Kita K, et al. J Biochem, 1989 May. PMID 2546925
    3. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Bassett JH, et al. PLoS Genet, 2012. PMID 22876197, Free PMC Article
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93257

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribose phosphate diphosphokinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoribosyl pyrophosphate synthase-associated protein 2
    Names
    41 kDa phosphoribosypyrophosphate synthetase-associated protein
    PRPP synthase-associated protein 2
    PRPP synthetase-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057131.2 → NP_476472.1  phosphoribosyl pyrophosphate synthase-associated protein 2

      See identical proteins and their annotated locations for NP_476472.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87
      Conserved Domains (2) summary
      pfam13793
      Location:20 → 138
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:179 → 363
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46910282..46945401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246436.5 → XP_006246498.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006246498.1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87
      Related
      ENSRNOP00000003697.2, ENSRNOT00000003697.5
      Conserved Domains (2) summary
      pfam13793
      Location:20 → 138
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:179 → 363
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    2. XM_063268335.1 → XP_063124405.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X3

    3. XM_039085083.2 → XP_038941011.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X6

      Conserved Domains (1) summary
      COG0462
      Location:18 → 211
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

    4. XM_006246440.5 → XP_006246502.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006246502.1

      Conserved Domains (1) summary
      COG0462
      Location:18 → 314
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

    5. XM_006246439.5 → XP_006246501.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006246501.1

      Conserved Domains (2) summary
      pfam13793
      Location:20 → 98
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:139 → 323
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    6. XM_008767764.4 → XP_008765986.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X4

      See identical proteins and their annotated locations for XP_008765986.1

      UniProtKB/TrEMBL
      Q6AZ40
      Conserved Domains (2) summary
      pfam13793
      Location:1 → 52
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:93 → 277
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    7. XM_006246437.5 → XP_006246499.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006246499.1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87
      Conserved Domains (2) summary
      pfam13793
      Location:20 → 138
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:179 → 363
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    8. XM_039085080.2 → XP_038941008.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

      Conserved Domains (2) summary
      pfam13793
      Location:20 → 98
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:139 → 323
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    9. XM_006246435.5 → XP_006246497.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006246497.1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87
      Conserved Domains (2) summary
      pfam13793
      Location:20 → 138
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:179 → 363
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    10. XM_063268327.1 → XP_063124397.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87

    11. XM_063268337.1 → XP_063124407.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X5

    12. XM_063268330.1 → XP_063124400.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87

    13. XM_063268338.1 → XP_063124408.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X6

    14. XM_063268336.1 → XP_063124406.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X3

    15. XM_039085078.2 → XP_038941006.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87
      Conserved Domains (2) summary
      pfam13793
      Location:20 → 138
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:179 → 363
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    16. XM_063268333.1 → XP_063124403.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

    17. XM_063268331.1 → XP_063124401.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87

    18. XM_063268332.1 → XP_063124402.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

    19. XM_063268329.1 → XP_063124399.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87

    20. XM_063268328.1 → XP_063124398.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87

    21. XM_063268326.1 → XP_063124396.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O08618
      UniProtKB/TrEMBL
      A6HF87
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08618.1 GenPept UniProtKB/Swiss-Prot:O08618

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