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    Amotl1 angiomotin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 75723, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Amotl1provided by MGI
    Official Full Name
    angiomotin-like 1provided by MGI
    Primary source
    MGI:MGI:1922973
    See related
    Ensembl:ENSMUSG00000013076 AllianceGenome:MGI:1922973
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JEAP; mFLJ00155; 2310010G08Rik; 2310067L22Rik; 4932416D09Rik
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within establishment of cell polarity involved in ameboidal cell migration and positive regulation of blood vessel endothelial cell migration. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Is expressed in brain and head. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 21.7), mammary gland adult (RPKM 16.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Amotl1 in Genome Data Viewer
    Location:
    9 A2; 9 4.12 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14453262..14574408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14541966..14662974, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 4D Neighboring gene STARR-positive B cell enhancer ABC_E248 Neighboring gene CWC15 spliceosome-associated protein Neighboring gene predicted gene, 34263 Neighboring gene STARR-seq mESC enhancer starr_23355 Neighboring gene predicted gene 7607 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Using human sequencing to guide craniofacial research. Liegel RP, et al. Genesis, 2019 Jan. PMID 30375152, Free PMC Article
    2. JEAP, a novel component of tight junctions in exocrine cells. Nishimura M, et al. J Biol Chem, 2002 Feb 15. PMID 11733531
    3. Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis. Zheng Y, et al. Sci Rep, 2016 Jul 28. PMID 27464479, Free PMC Article
    4. Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation. Matsumoto H, et al. J Reprod Dev, 2012. PMID 22813598
    5. Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Aase K, et al. Genes Dev, 2007 Aug 15. PMID 17699752, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fat4 is not required for the canonical activation of Hippo kinases but it sequesters a partner of Yap1, Amotl1, out of the nucleus.
      Title: Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.
    2. The authors propose that AmotL1 is an essential effector of the N-cadherin mediated endothelial/pericyte junctional complex.
      Title: Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis.
    3. These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs.
      Title: The role of tumor necrosis factor-α and interferon-γ in regulating angiomotin-like protein 1 expression in lung microvascular endothelial cells.
    4. Amot, Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri-implantation period.
      Title: Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.
    5. Amot and AmotL1 have similar effects on endothelial migration and tight junction formation in vitro. In vivo Amot appears to control the cell polarity and AmotL1 affects the stability of cell-cell junctions.
      Title: Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis.
    6. Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1.
      Title: Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00155

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity involved in ameboidal cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of cell polarity involved in ameboidal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiomotin-like protein 1
    Names
    junction-enriched and -associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081395.1 → NP_001074864.1  angiomotin-like protein 1

      See identical proteins and their annotated locations for NP_001074864.1

      Status: PROVISIONAL

      Source sequence(s)
      CT030247, CT485607
      Consensus CDS
      CCDS40535.1
      UniProtKB/Swiss-Prot
      B9EKN5, Q571F1, Q9D4H4
      Related
      ENSMUSP00000013220.7, ENSMUST00000013220.8
      Conserved Domains (3) summary
      pfam12240
      Location:616 → 818
      Angiomotin_C; Angiomotin C terminal
      cl02475
      Location:16 → 51
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl12013
      Location:478 → 650
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      14453262..14574408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510666.4 → XP_006510729.1  angiomotin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VM69
      Related
      ENSMUSP00000152834.2, ENSMUST00000223132.2
      Conserved Domains (2) summary
      COG1196
      Location:486 → 741
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:653 → 855
      Angiomotin_C; Angiomotin C terminal

    2. XM_036155371.1 → XP_036011264.1  angiomotin-like protein 1 isoform X4

      Conserved Domains (2) summary
      TIGR02169
      Location:358 → 619
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam12240
      Location:530 → 736
      Angiomotin_C; Angiomotin C terminal

    3. XM_006510667.4 → XP_006510730.1  angiomotin-like protein 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:485 → 740
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:652 → 854
      Angiomotin_C; Angiomotin C terminal

    4. XM_030244693.2 → XP_030100553.1  angiomotin-like protein 1 isoform X4

      Conserved Domains (2) summary
      TIGR02169
      Location:358 → 619
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam12240
      Location:530 → 736
      Angiomotin_C; Angiomotin C terminal

    5. XM_006510670.3 → XP_006510733.1  angiomotin-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006510733.1

      UniProtKB/Swiss-Prot
      Q9D4H4
      Conserved Domains (2) summary
      TIGR02169
      Location:358 → 619
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam12240
      Location:530 → 736
      Angiomotin_C; Angiomotin C terminal

    6. XM_006510668.2 → XP_006510731.1  angiomotin-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006510731.1

      UniProtKB/Swiss-Prot
      Q9D4H4
      Conserved Domains (2) summary
      TIGR02169
      Location:358 → 619
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam12240
      Location:530 → 736
      Angiomotin_C; Angiomotin C terminal

    7. XM_030244692.2 → XP_030100552.1  angiomotin-like protein 1 isoform X3

      Conserved Domains (3) summary
      COG1196
      Location:448 → 703
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl02475
      Location:16 → 51
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam12240
      Location:615 → 817
      Angiomotin_C; Angiomotin C terminal

    8. XM_006510669.4 → XP_006510732.1  angiomotin-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006510732.1

      UniProtKB/Swiss-Prot
      Q9D4H4
      Conserved Domains (2) summary
      TIGR02169
      Location:358 → 619
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam12240
      Location:530 → 736
      Angiomotin_C; Angiomotin C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4H4.2 GenPept UniProtKB/Swiss-Prot:Q9D4H4

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