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    Klhl28 kelch-like 28 [ Mus musculus (house mouse) ]

    Gene ID: 66689, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klhl28provided by MGI
    Official Full Name
    kelch-like 28provided by MGI
    Primary source
    MGI:MGI:1913939
    See related
    Ensembl:ENSMUSG00000020948 AllianceGenome:MGI:1913939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Btbd5; 2810440N09Rik; 4122402F11Rik; 4931401E10Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in ganglia and sensory organ. Orthologous to human KLHL28 (kelch like family member 28). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 2.1), CNS E18 (RPKM 2.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl28 in Genome Data Viewer
    Location:
    12 C1; 12 27.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (64985603..65012365, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (64941486..64965581, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_32310 Neighboring gene STARR-positive B cell enhancer mm9_chr12:66018613-66018914 Neighboring gene predicted gene, 51965 Neighboring gene predicted gene 527 Neighboring gene TOG array regulator of axonemal microtubules 1 Neighboring gene STARR-seq mESC enhancer starr_32311 Neighboring gene STARR-positive B cell enhancer ABC_E7138 Neighboring gene predicted gene, 51966 Neighboring gene STARR-seq mESC enhancer starr_32313 Neighboring gene pre-mRNA processing factor 39 Neighboring gene predicted gene, 25970

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47075

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 28
    Names
    BTB (POZ) domain containing 5
    BTB/POZ domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025707.3 → NP_079983.1  kelch-like protein 28

      See identical proteins and their annotated locations for NP_079983.1

      Status: PROVISIONAL

      Source sequence(s)
      AC159632
      Consensus CDS
      CCDS25938.1
      UniProtKB/Swiss-Prot
      Q9CR40, Q9CYV0
      Related
      ENSMUSP00000152602.2, ENSMUST00000222508.2
      Conserved Domains (2) summary
      PHA03098
      Location:35 → 553
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 465
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      64985603..65012365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516156.5 → XP_006516219.1  kelch-like protein 28 isoform X1

      See identical proteins and their annotated locations for XP_006516219.1

      UniProtKB/Swiss-Prot
      Q9CR40, Q9CYV0
      Related
      ENSMUSP00000021331.8, ENSMUST00000021331.9
      Conserved Domains (2) summary
      PHA03098
      Location:35 → 553
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 465
      Kelch; KELCH repeat [structural motif]

    2. XM_006516157.5 → XP_006516220.1  kelch-like protein 28 isoform X2

      Conserved Domains (3) summary
      PHA03098
      Location:35 → 522
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:376 → 419
      Kelch; KELCH repeat [structural motif]
      cd18257
      Location:17 → 134
      BTB_POZ_KLHL28_BTBD5; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR40.1 GenPept UniProtKB/Swiss-Prot:Q9CR40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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