Col14a1 collagen, type XIV, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Col14a1provided by MGI
Official Full Name: collagen, type XIV, alpha 1provided by MGI
Primary source: MGI:MGI:1341272
See related: Ensembl:ENSMUSG00000022371 AllianceGenome:MGI:1341272
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730412L22Rik
Summary: Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within several processes, including collagen fibril organization; regulation of cell growth involved in cardiac muscle cell development; and ventricular cardiac muscle tissue development. Located in interstitial matrix. Is expressed in several structures, including cranium; genitourinary system; gut; heart and pericardium; and skeletal musculature. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human COL14A1 (collagen type XIV alpha 1 chain). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 45.3), limb E14.5 (RPKM 16.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.96 cM

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (55171040..55384199)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (55307644..55520803)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collagen XIV Is an Intrinsic Regulator of Corneal Stromal Structure and Function.
Title: Collagen XIV Is an Intrinsic Regulator of Corneal Stromal Structure and Function.
polymorphisms in Ambn, Col14a1, and Mmp20 are associated with the susceptibility to dental fluorosis
Title: Analysis of Polymorphisms in Genes Differentially Expressed in the Enamel of Mice with Different Genetic Susceptibilities to Dental Fluorosis.
Col14a1 deficiency leads to a greater increase in left ventricular wall thickening in response to pathological pressure overload compared to wild type animals.
Title: Collagen XIV is important for growth and structural integrity of the myocardium.
a regulatory function for type XIV collagen in early stages of collagen fibrillogenesis with tissue differences
Title: Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE.
The 6456 nucleotide (nt) cDNA contains 5391-nt open reading frame encoding 1797 amino acid residues. Amino terminus has a28-residue signal peptide followed by mature polypeptide of 1769 amino acid residues with calculated molecular mass of 193.2 kDa.
Title: Complete primary structure and genomic organization of the mouse Col14a1 gene.
The entire mouse cDNA sequence for type XIV collagen was determined using overlapping PCR products. The 6456 nucleotide (nt) cDNA sequence contains a 5391-nt open reading frame encoding 1797 amino acid residues.
Title: Complete primary structure and genomic organization of the mouse Col14a1 gene.
the fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes
Title: The elongated first fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

17.MMHAP59FLF2.seq (e-PCR)
- UniSTS:123347

AJ131395 (e-PCR)
- UniSTS:163555

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring tensile strength	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in interstitial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in interstitial matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: collagen alpha-1(XIV) chain

Names: procollagen, type XIV, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368422.1 → NP_001355351.1 collagen alpha-1(XIV) chain isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC131337, AC133156

Consensus CDS

CCDS88765.1

UniProtKB/Swiss-Prot

Q3UVS2, Q80X19, Q8C6X3, Q9WV05

Related

ENSMUSP00000023053.6, ENSMUST00000023053.12

Conserved Domains (7) summary

smart00060
Location:740 → 818

FN3; Fibronectin type 3 domain

smart00210
Location:1230 → 1425

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 622

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:1032 → 1196

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:355 → 433

fn3; Fibronectin type III domain

pfam01391
Location:1516 → 1605

Collagen; Collagen triple helix repeat (20 copies)

cl21522
Location:923 → 998

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_181277.4 → NP_851794.3 collagen alpha-1(XIV) chain isoform 2 precursor

See identical proteins and their annotated locations for NP_851794.3

Status: VALIDATED

Source sequence(s)

AC131337, AC133156

Consensus CDS

CCDS37076.1

UniProtKB/TrEMBL

B7ZNH7

Related

ENSMUSP00000105850.3, ENSMUST00000110221.10

Conserved Domains (6) summary

pfam01391
Location:1481 → 1602

Collagen; Collagen triple helix repeat (20 copies)

smart00060
Location:448 → 517

FN3; Fibronectin type 3 domain

smart00210
Location:1227 → 1422

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 622

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:1029 → 1193

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:828 → 906

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

55171040..55384199

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520385.4 → XP_006520448.1 collagen alpha-1(XIV) chain isoform X1

Conserved Domains (6) summary

pfam01391
Location:1484 → 1605

Collagen; Collagen triple helix repeat (20 copies)

smart00060
Location:448 → 517

FN3; Fibronectin type 3 domain

smart00210
Location:1230 → 1425

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 622

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:1032 → 1196

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:355 → 433

fn3; Fibronectin type III domain
XM_036159113.1 → XP_036015006.1 collagen alpha-1(XIV) chain isoform X2

Conserved Domains (7) summary

smart00060
Location:448 → 517

FN3; Fibronectin type 3 domain

smart00210
Location:1227 → 1422

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 622

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:1029 → 1193

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:355 → 433

fn3; Fibronectin type III domain

pfam01391
Location:1513 → 1602

Collagen; Collagen triple helix repeat (20 copies)

cl21522
Location:920 → 995

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...