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    Pabir2 PABIR family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 78755, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pabir2provided by MGI
    Official Full Name
    PABIR family member 2provided by MGI
    Primary source
    MGI:MGI:1926005
    See related
    Ensembl:ENSMUSG00000036022 AllianceGenome:MGI:1926005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam122b; SPACIA2; 4632404H22Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase inhibitor activity. Is expressed in several structures, including central nervous system; hindlimb digit mesenchyme; sensory organ; skeleton; and trachea. Orthologous to human PABIR2 (PABIR family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 12.7), limb E14.5 (RPKM 5.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pabir2 in Genome Data Viewer
    Location:
    X A5; X 29.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52332292..52358728, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53243415..53269850, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized LOC119919412 Neighboring gene STARR-seq mESC enhancer starr_47192 Neighboring gene Mir503, Mir351, and Mir322 host gene Neighboring gene microRNA 322 Neighboring gene predicted gene, 35988 Neighboring gene placental specific protein 1 Neighboring gene PABIR family member 3 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene motile sperm domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans. Sato T, et al. Arthritis Rheum, 2011 Dec. PMID 22127701
    2. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    PABIR family member 2
    Names
    family with sequence similarity 122, member B
    protein FAM122B
    synoviocyte proliferation associated in collagen-induced arthritis 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166365.2 → NP_001159837.2  PABIR family member 2 isoform 1

      See identical proteins and their annotated locations for NP_001159837.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      AK019480, AK044896, BB068834
      Consensus CDS
      CCDS53070.1
      UniProtKB/Swiss-Prot
      B1B0Y4, B1B0Y5, Q6NZE7, Q8BRG5, Q8CBB0, Q9D2N2
      UniProtKB/TrEMBL
      G1UD78
      Related
      ENSMUSP00000110487.2, ENSMUST00000114838.8

    2. NM_001166583.1 → NP_001160055.1  PABIR family member 2 isoform 3

      See identical proteins and their annotated locations for NP_001160055.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK036417, AK044896, BB068834, BX519788
      Consensus CDS
      CCDS53069.1
      UniProtKB/Swiss-Prot
      Q6NZE7
      Related
      ENSMUSP00000110490.2, ENSMUST00000114841.2

    3. NM_030167.4 → NP_084443.1  PABIR family member 2 isoform 2

      See identical proteins and their annotated locations for NP_084443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that adds one codon to the internal coding region, compared to variant 1. This variant encodes isoform 2.
      Source sequence(s)
      AK019480, AK044896, BB068834
      Consensus CDS
      CCDS30129.1
      UniProtKB/Swiss-Prot
      Q6NZE7
      Related
      ENSMUSP00000069112.6, ENSMUST00000071023.12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      52332292..52358728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541556.5 → XP_006541619.1  PABIR family member 2 isoform X1

    2. XM_036162120.1 → XP_036018013.1  PABIR family member 2 isoform X2

    3. XM_030251521.2 → XP_030107381.1  PABIR family member 2 isoform X6

    4. XM_011251023.4 → XP_011249325.1  PABIR family member 2 isoform X4

    5. XM_036162122.1 → XP_036018015.1  PABIR family member 2 isoform X5

    6. XM_036162121.1 → XP_036018014.1  PABIR family member 2 isoform X3

    7. XM_006541557.5 → XP_006541620.1  PABIR family member 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZE7.2 GenPept UniProtKB/Swiss-Prot:Q6NZE7

    Gene LinkOut

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