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    PEG10 paternally expressed 10 [ Echinops telfairi (small Madagascar hedgehog) ]

    Gene ID: 101655027, updated on 20-Sep-2024

    Summary

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    Gene symbol
    PEG10
    Gene description
    paternally expressed 10
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Echinops telfairi
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tenrecidae; Tenrecinae; Echinops
    Summary
    This gene is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See PEG10 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    103 current ASM31398v2 (GCF_000313985.2) Unplaced Scaffold NW_022103920.1 (60774813..60783604)
    101 previous assembly EchTel2.0 (GCF_000313985.1) Unplaced Scaffold NW_004558713.1 (31651479..31660270)

    NW_022103920.1Genomic Context describing neighboring genes Neighboring gene CAS1 domain containing 1 Neighboring gene sarcoglycan epsilon Neighboring gene small nucleolar RNA SNORA18 Neighboring gene protein phosphatase 1 regulatory subunit 9A Neighboring gene guanine nucleotide exchange C9orf72-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and molecular analyses of PEG10 reveal new aspects of genomic organization, transcription and translation. Lux H, et al. PLoS One, 2010 Jan 13. PMID 20084274, Free PMC Article
    2. Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. Clark MB, et al. J Biol Chem, 2007 Dec 28. PMID 17942406
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retrotransposon-derived protein PEG10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291193.1 → NP_001278122.1  retrotransposon-derived protein PEG10 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This longer isoform (1) is derived from RF1/RF2 by -1 translational frameshifting.
      Source sequence(s)
      AAIY03000025
      Conserved Domains (5) summary
      cd00303
      Location:474 → 558
      retropepsin_like; Retropepsins; pepsin-like aspartate proteases
      pfam03732
      Location:226 → 319
      Retrotrans_gag; Retrotransposon gag protein
      cd14686
      Location:65 → 115
      bZIP; coiled coil [structural motif]
      pfam16297
      Location:185 → 265
      DUF4939; Domain of unknown function (DUF4939)
      cl21462
      Location:65 → 121
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. NM_001291194.1 → NP_001278123.1  retrotransposon-derived protein PEG10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This isoform (2) produced from RF1 in the absence of -1 translational frameshifting has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AAIY03000025
      Conserved Domains (4) summary
      pfam03732
      Location:226 → 319
      Retrotrans_gag; Retrotransposon gag protein
      cd14686
      Location:65 → 115
      bZIP; coiled coil [structural motif]
      pfam16297
      Location:185 → 265
      DUF4939; Domain of unknown function (DUF4939)
      cl21462
      Location:65 → 121
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Echinops telfairi Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM31398v2 Primary Assembly

    Genomic

    1. NW_022103920.1 Reference ASM31398v2 Primary Assembly

      Range
      60774813..60783604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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