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    APOE apolipoprotein E [ Monodelphis domestica (gray short-tailed opossum) ]

    Gene ID: 100023758, updated on 8-May-2024

    Summary

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    Gene symbol
    APOE
    Gene description
    apolipoprotein E
    See related
    EnsemblRapid:ENSMODG00000038504
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Monodelphis domestica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
    Orthologs
    human mouse all
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    Genomic context

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    See APOE in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 4 NC_077230.1 (422160516..422163270, complement)
    103 previous assembly MonDom5 (GCF_000002295.2) 4 NC_008804.1 (370768857..370771174)

    Chromosome 4 - NC_077230.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein C2 Neighboring gene apolipoprotein C-I Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene nectin cell adhesion molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables very-low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipoprotein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of intermediate-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apolipoprotein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mMonDom1.pri

    Genomic

    1. NC_077230.1 Reference mMonDom1.pri

      Range
      422160516..422163270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007491572.2 → XP_007491634.1  apolipoprotein E

      See identical proteins and their annotated locations for XP_007491634.1

      UniProtKB/TrEMBL
      A0A5F8HC70
      Related
      ENSMODP00000057511.2, ENSMODT00000075787.2
      Conserved Domains (2) summary
      pfam01442
      Location:85 → 253
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam05778
      Location:47 → 91
      Apo-CIII; Apolipoprotein CIII (Apo-CIII)

    2. XM_007491571.2 → XP_007491633.1  apolipoprotein E

      See identical proteins and their annotated locations for XP_007491633.1

      UniProtKB/TrEMBL
      A0A5F8HC70
      Related
      ENSMODP00000083217.1, ENSMODT00000089750.1
      Conserved Domains (2) summary
      pfam01442
      Location:85 → 253
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam05778
      Location:47 → 91
      Apo-CIII; Apolipoprotein CIII (Apo-CIII)
    Nucleotide Protein
    Heading Accession and Version

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