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    Scp1 Sarcoplasmic calcium-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355102, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Scp1provided by FlyBase
    Official Full Name
    Sarcoplasmic calcium-binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0020908
    Locus tag
    Dmel_CG15848
    See related
    AllianceGenome:FB:FBgn0020908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH15296; CG15848; Dcabp-A.1; Dmel\CG15848; SCP
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in calcium-ion regulated exocytosis. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and mesothoracic tergotrochanter muscle cell. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Scp1 in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (2932595..2968052, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (1707564..1743021, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46481 Neighboring gene defective proboscis extension response 21 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a gene family from Drosophila melanogaster encoding proteins with homology to invertebrate sarcoplasmic calcium-binding proteins (SCPS). Kelly LE, et al. Insect Biochem Mol Biol, 1997 Aug-Sep. PMID 9443378
    2. HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. Lin CH, et al. PLoS One, 2012. PMID 22761891, Free PMC Article
    3. Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model. Sharma A, et al. PLoS One, 2009 Jun 2. PMID 19503609, Free PMC Article
    4. Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity. Vujatovic O, et al. Nucleic Acids Res, 2012 Jul. PMID 22406835, Free PMC Article
    5. Label-free quantitative mass spectrometry analysis of the circadian proteome of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin. Wong KC, et al. Arch Insect Biochem Physiol, 2023 Jun. PMID 36915983

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c2946018-2945333 mobile_element_type = transposon:1360{}6345

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sarcoplasmic calcium-binding protein 1
    Names
    CG15848-PA
    CG15848-PB
    Scp1-PA
    Scp1-PB
    calcium biding protein
    drosophila Ca[2+]-binding protein A.1
    sarcoplasmic calcium binding protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      2932595..2968052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276231.1 → NP_001263160.1  sarcoplasmic calcium-binding protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16157, Q8MSI2
      Conserved Domains (2) summary
      pfam13499
      Location:15 → 86
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:16 → 87
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_001015389.3 → NP_001015389.1  sarcoplasmic calcium-binding protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015389.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16157, Q8MSI2
      Conserved Domains (2) summary
      pfam13499
      Location:15 → 86
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:16 → 87
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16157 O16157
    Q8MSI2 Q8MSI2

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