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    FRT2 Frt2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851205, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FRT2
    Official Full Name
    Frt2p
    Primary source
    SGD:S000000026
    Locus tag
    YAL028W
    See related
    AllianceGenome:SGD:S000000026; FungiDB:YAL028W; VEuPathDB:YAL028W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HPH2
    Summary
    Involved in cellular response to alkaline pH and cellular response to salt stress. Acts upstream of or within posttranslational protein targeting to membrane, translocation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FRT2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (92900..94486)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene SNAP receptor SNC1 Neighboring gene myosin 4 Neighboring gene DNA-binding protein SAW1 Neighboring gene aminophospholipid-translocating P4-type ATPase DRS2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Heath VL, et al. Eukaryot Cell, 2004 Jun. PMID 15189990, Free PMC Article
    2. Genetic architecture of Hsp90-dependent drug resistance. Cowen LE, et al. Eukaryot Cell, 2006 Dec. PMID 17056742, Free PMC Article
    3. Yeast adapts to a changing stressful environment by evolving cross-protection and anticipatory gene regulation. Dhar R, et al. Mol Biol Evol, 2013 Mar. PMID 23125229
    4. Metabolic control of antifungal drug resistance. Robbins N, et al. Fungal Genet Biol, 2010 Feb. PMID 19595784
    5. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. Piña FJ, et al. Eukaryot Cell, 2011 Jan. PMID 21097665, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis
      Title: Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis.
    2. Hph2p neither interacts with nor is dephosphorylated by calcineurin.
      Title: Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-translational protein targeting to membrane, translocation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Frt2p
    NP_009374.1
    • Tail-anchored ER membrane hypothetical protein; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      92900..94486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178173.1 → NP_009374.1  TPA: Frt2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPJ0, P39733, P39734
      UniProtKB/TrEMBL
      B3LUW2, C7GPK7, N1PAY9
      Conserved Domains (1) summary
      pfam13694
      Location:86 → 280
      Hph; Sec63/Sec62 complex-interacting family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39734.2

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