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    CYK3 Cyk3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851440, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CYK3
    Official Full Name
    Cyk3p
    Primary source
    SGD:S000002275
    Locus tag
    YDL117W
    See related
    AllianceGenome:SGD:S000002275; FungiDB:YDL117W; VEuPathDB:YDL117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme regulator activity. Involved in secondary cell septum biogenesis. Located in cellular bud neck contractile ring. Part of HICS complex. Human ortholog(s) of this gene implicated in myofibrillar myopathy 7. Orthologous to human KY (kyphoscoliosis peptidase). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CYK3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (248581..251238)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ferroxidase Neighboring gene Hem25p Neighboring gene Nup84p Neighboring gene Iwr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Oh Y, et al. Mol Biol Cell, 2012 Jul. PMID 22573892, Free PMC Article
    2. Cyk3, a novel SH3-domain protein, affects cytokinesis in yeast. Korinek WS, et al. Curr Biol, 2000 Jul 27-Aug 10. PMID 10959846
    3. The kinetic landscape and interplay of protein networks in cytokinesis. Okada H, et al. iScience, 2021 Jan 22. PMID 33392480, Free PMC Article
    4. Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. Devrekanli A, et al. J Cell Sci, 2012 Nov 15. PMID 22956544
    5. Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. Wang M, et al. Mol Biol Cell, 2018 Mar 1. PMID 29321253, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hof1 and Cyk3 interact directly at the time of cytokinesis by means of their respective SH3 and proline-rich domains
      Title: Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis.
    2. Dephosphorylation of Inn1 by Cdc14 stabilizes the interaction between Inn1 and Cyk3.
      Title: Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation.
    3. Cyk3 is part of an actomyosin ring independent cytokinesis pathway, which acts as a rescue mechanism to recruit Inn1 to the bud neck.
      Title: Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck.
    4. Data show that the Inn1 C-terminal region is necessary for localization, and distinct PXXP motifs in this region mediate functionally important interactions with SH3 domains in the cytokinesis proteins Hof1 and Cyk3.
      Title: Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic division septum assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in secondary cell septum biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in secondary cell septum biogenesis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HICS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Cyk3p
    NP_010166.1
    • SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      248581..251238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180176.1 → NP_010166.1  TPA: Cyk3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRN3, Q07533
      UniProtKB/TrEMBL
      G2WC44, N1P411
      Conserved Domains (2) summary
      COG5279
      Location:28 → 882
      CYK3; Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle control, cell division, chromosome partitioning]
      cl17036
      Location:13 → 65
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07533.1

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