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    PCL6 Pcl6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856787, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PCL6
    Official Full Name
    Pcl6p
    Primary source
    SGD:S000000861
    Locus tag
    YER059W
    See related
    AllianceGenome:SGD:S000000861; FungiDB:YER059W; VEuPathDB:YER059W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Predicted to be located in cytoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PCL6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (272624..273886)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative isoleucine biosynthesis protein HMF1 Neighboring gene Pet117p Neighboring gene purine-cytosine permease Neighboring gene purine-cytosine permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding to Elongin C inhibits degradation of interacting proteins in yeast. Hyman LE, et al. J Biol Chem, 2002 May 3. PMID 11864988
    2. Analysis of phosphorylation of YJL084c, a yeast protein. Shi XZ, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Jul. PMID 12098764
    3. The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p. Wang Z, et al. FEBS Lett, 2001 Oct 12. PMID 11602261
    4. The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1. Deprez MA, et al. PLoS Genet, 2023 Feb. PMID 36791155, Free PMC Article
    5. Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. Tan YS, et al. J Biol Chem, 2003 Jan 3. PMID 12407105

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of glycogen catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pcl6p
    NP_010980.1
    • Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      272624..273886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178950.1 → NP_010980.1  TPA: Pcl6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLW3, P40038
      UniProtKB/TrEMBL
      A6ZR12, B3LS74, B5VHJ0, C7GWI8, C8Z765
      Conserved Domains (1) summary
      pfam08613
      Location:170 → 388
      Cyclin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40038.1

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