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    VMR1 putative ATP-binding cassette multidrug transporter VMR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856350, updated on 2-Nov-2024

    Summary

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    Official Symbol
    VMR1
    Official Full Name
    putative ATP-binding cassette multidrug transporter VMR1
    Primary source
    SGD:S000001027
    Locus tag
    YHL035C
    See related
    AllianceGenome:SGD:S000001027; FungiDB:YHL035C; VEuPathDB:YHL035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ABC-type xenobiotic transporter activity. Involved in response to metal ion and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in fungal-type vacuole membrane. Orthologous to human ABCC10 (ATP binding cassette subfamily C member 10). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See VMR1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (27978..32756, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mup3p Neighboring gene Sbp1p Neighboring gene ribosomal 60S subunit protein L8A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae. Wawrzycka D, et al. FEMS Yeast Res, 2010 Nov. PMID 20846144
    2. Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae. Gueldry O, et al. Eur J Biochem, 2003 Jun. PMID 12755704
    3. Complete inventory of the yeast ABC proteins. Decottignies A, et al. Nat Genet, 1997 Feb. PMID 9020838
    4. ABCC subfamily vacuolar transporters are involved in Pb (lead) detoxification in Saccharomyces cerevisiae. Sousa CA, et al. Appl Biochem Biotechnol, 2015 Jan. PMID 25240850
    5. N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strains. Al-Attrache H, et al. Drug Chem Toxicol, 2018 Jan. PMID 28504001

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-binding cassette multidrug transporter VMR1
    NP_011828.1
    • Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      27978..32756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179115.1 → NP_011828.1  TPA: putative ATP-binding cassette multidrug transporter VMR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKT3, P38735
      UniProtKB/TrEMBL
      C7GRT7, N1P2U4
      Conserved Domains (1) summary
      TIGR00957
      Location:212 → 1575
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38735.1

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