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    NNK1 protein kinase NNK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853683, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NNK1
    Official Full Name
    protein kinase NNK1
    Primary source
    SGD:S000001654
    Locus tag
    YKL171W
    See related
    AllianceGenome:SGD:S000001654; FungiDB:YKL171W; VEuPathDB:YKL171W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in proteolysis. Located in cytoplasm. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See NNK1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (127475..130261)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene U5 snRNP GTPase SNU114 Neighboring gene Ebp2p Neighboring gene mitochondrial 54S ribosomal protein YmL38/YmL34 Neighboring gene putative serine/threonine protein kinase KKQ8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic screening of protein modifications in four kinases using affinity enrichment and mass spectrometry analysis with unrestrictive sequence alignment. Zhang K, et al. Anal Chim Acta, 2011 Apr 8. PMID 21458632
    2. Mitochondrial protein phosphorylation: lessons from yeasts. Tomaska L. Gene, 2000 Sep 5. PMID 10974565
    3. Saccharomyces cerevisiae gene YMR291W/TDA1 mediates the in vivo phosphorylation of hexokinase isoenzyme 2 at serine-15. Kettner K, et al. FEBS Lett, 2012 Feb 17. PMID 22289182
    4. Classification and functional annotation of eukaryotic protein kinases. Miranda-Saavedra D, et al. Proteins, 2007 Sep 1. PMID 17557329
    5. Quantification of oxidative stress phenotypes based on high-throughput growth profiling of protein kinase and phosphatase knockouts. Altıntaş A, et al. FEMS Yeast Res, 2016 Feb. PMID 26564984

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase NNK1
    NP_012750.1
    • Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      127475..130261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179737.1 → NP_012750.1  TPA: protein kinase NNK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX29, P36003
      UniProtKB/TrEMBL
      G2WHM1, N1NZM9
      Conserved Domains (2) summary
      cd00180
      Location:455 → 613
      PKc; Catalytic domain of Protein Kinases
      cl21453
      Location:817 → 864
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36003.1

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