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    CCL23 C-C motif chemokine ligand 23 [ Homo sapiens (human) ]

    Gene ID: 6368, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CCL23provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 23provided by HGNC
    Primary source
    HGNC:HGNC:10622
    See related
    Ensembl:ENSG00000274736 MIM:602494; AllianceGenome:HGNC:10622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8
    Summary
    This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in appendix (RPKM 3.6), lung (RPKM 2.2) and 15 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CCL23 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36013058..36017972, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36960963..36965877, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34340098..34345009, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene C-C motif chemokine ligand 14 Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:34350127-34350628 Neighboring gene uncharacterized LOC105371746 Neighboring gene C-C motif chemokine ligand 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer. Kamat K, et al. Br J Cancer, 2022 Oct. PMID 35750747, Free PMC Article
    2. Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23. Miao Z, et al. J Immunol, 2007 Jun 1. PMID 17513790
    3. Associations of four circulating chemokines with multiple atherosclerosis phenotypes in a large population-based sample: results from the dallas heart study. Castillo L, et al. J Interferon Cytokine Res, 2010 May. PMID 20187767, Free PMC Article
    4. Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells. Son KN, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16378600
    5. Serum CCL23 levels are increased in patients with systemic sclerosis. Yanaba K, et al. Arch Dermatol Res, 2011 Jan. PMID 20824279

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Delayed CCL23 response is associated with poor outcomes after cardiac arrest.
      Title: Delayed CCL23 response is associated with poor outcomes after cardiac arrest.
    2. Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.
      Title: Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.
    3. Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma.
      Title: Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma.
    4. CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.
      Title: CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.
    5. CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease.
      Title: CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease.
    6. The low expression of CCL23 in hepatocellular carcinoma (HCC) tissue is not conducive to the development of anti-tumor immune defense in HCC patients and significantly shortens the survival of HCC patients.
      Title: [Bioinformatics analysis and significance of expression of CC chemokine ligand 23 (CCL23) in hepatocellular carcinoma].
    7. CCL23 is posttranslationally modified by trypsin-like serine proteases and CCL23(47-117) might be a major active form of CCL23 in nasal polyps with chronic rhinosinusitis.
      Title: Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis.
    8. The coexistence of diabetes and oxidative stress independently affected CCL23 levels, while the presence of Cardiovascular disease and inflammation had no impact on its concentrations.
      Title: Effect of diabetes and oxidative stress on plasma CCL23 levels in patients with severe chronic kidney disease.
    9. ADAMTS 8, CCL23, and TNFSF15 are implicated in anti-angiogenic activities
      Title: Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease.
    10. Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis.
      Title: Potential involvement of CCL23 in atherosclerotic lesion formation/progression by the enhancement of chemotaxis, adhesion molecule expression, and MMP-2 release from monocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of lung function phenotypes in a founder population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates the gene expression of CCL23 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CCR1 chemokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in monocyte chemotaxis IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C-C motif chemokine 23
    Names
    C6 beta-chemokine
    chemokine (C-C motif) ligand 23
    macrophage inflammatory protein 3
    myeloid progenitor inhibitory factor 1
    small inducible cytokine subfamily A (Cys-Cys), member 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029876.2 RefSeqGene

      Range
      4997..9911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005064.6 → NP_005055.3  C-C motif chemokine 23 isoform CKbeta8-1 precursor

      See identical proteins and their annotated locations for NP_005055.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (CKbeta8-1) represents the longer transcript and encodes the longer isoform (CKbeta8-1).
      Source sequence(s)
      AC244100, BC143310, U58913, U85767
      Consensus CDS
      CCDS11305.1
      UniProtKB/Swiss-Prot
      P55773
      Related
      ENSP00000481357.1, ENST00000615050.2
      Conserved Domains (1) summary
      smart00199
      Location:68 → 126
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    2. NM_145898.4 → NP_665905.2  C-C motif chemokine 23 isoform CKbeta8 precursor

      See identical proteins and their annotated locations for NP_665905.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (CKbeta8) uses an alternate, in-frame splice site in the coding region, compared to transcript variant CKbeta8-1. This difference results in a shorter protein (isoform CKbeta8) compared to isoform CKbeta8-1.
      Source sequence(s)
      AC244100, BC093970, U58913, U85767
      Consensus CDS
      CCDS59282.1
      UniProtKB/Swiss-Prot
      B7ZKQ3, O00174, O75950, P55773, Q52LD4
      Related
      ENSP00000484748.1, ENST00000612516.4
      Conserved Domains (1) summary
      smart00199
      Location:51 → 109
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      36013058..36017972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      247626..252537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36960963..36965877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55773.4 GenPept UniProtKB/Swiss-Prot:P55773

    Gene LinkOut

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