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    Nup133 nucleoporin 133 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292085, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nup133provided by RGD
    Official Full Name
    nucleoporin 133provided by RGD
    Primary source
    RGD:1307827
    See related
    EnsemblRapid:ENSRNOG00000017919 AllianceGenome:RGD:1307827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore organization; nucleocytoplasmic transport; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to act upstream of or within nervous system development; paraxial mesoderm development; and somite development. Predicted to be located in kinetochore and nuclear membrane. Predicted to be part of nuclear pore outer ring. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 104.6), Spleen (RPKM 83.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nup133 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68789065..68838692, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51891606..51941243, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56681965..56731404, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348965 Neighboring gene U6 spliceosomal RNA Neighboring gene actin, alpha 1, skeletal muscle Neighboring gene uncharacterized LOC134483405 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene ATP binding cassette subfamily B member 10 Neighboring gene TATA-box binding protein associated factor 5 like 1 Neighboring gene URB2 ribosome biogenesis homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex. Schrader N, et al. Structure, 2008 Jul. PMID 18611384
    2. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. Vasu S, et al. J Cell Biol, 2001 Oct 29. PMID 11684705, Free PMC Article
    3. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. Belgareh N, et al. J Cell Biol, 2001 Sep 17. PMID 11564755, Free PMC Article
    4. Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. Braun DA, et al. J Clin Invest, 2018 Oct 1. PMID 30179222, Free PMC Article
    5. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A, et al. Genes (Basel), 2014 Sep 2. PMID 25184662, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nephron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear pore organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within paraxial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup133

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400955.1 → NP_001387884.1  nuclear pore complex protein Nup133

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      D3Z8B2
      Related
      ENSRNOP00000024182.6, ENSRNOT00000024182.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68789065..68838692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772671.4 → XP_008770893.1  nuclear pore complex protein Nup133 isoform X1

      See identical proteins and their annotated locations for XP_008770893.1

      UniProtKB/TrEMBL
      A0A8I6A7P7
      Conserved Domains (1) summary
      pfam03177
      Location:469 → 954
      Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

    2. XM_039098297.2 → XP_038954225.1  nuclear pore complex protein Nup133 isoform X2

      Conserved Domains (1) summary
      pfam03177
      Location:61 → 460
      Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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