Ddt D-dopachrome tautomerase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddtprovided by MGI
Official Full Name: D-dopachrome tautomeraseprovided by MGI
Primary source: MGI:MGI:1298381
See related: Ensembl:ENSMUSG00000001666 AllianceGenome:MGI:1298381
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protease binding activity. Involved in positive regulation of inflammatory response. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to several human genes including DDT (D-dopachrome tautomerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 301.3), liver E18 (RPKM 164.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.58 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75607067..75609208, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75771233..75773374, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer.
Title: Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer.
Cardiomyocyte d-dopachrome tautomerase protects against heart failure.
Title: Cardiomyocyte d-dopachrome tautomerase protects against heart failure.
TWEAK upregulates CD74 and its ligands MIF and DDT in renal tubular cells.
Title: TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.
cardiomyocyte secretion of DDT has important autocrine/paracrine effects during ischemia-reperfusion that protect the heart against injury
Title: The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury.
These data point to a potential involvement of D-dopachrome tautomerase activity in the mature mouse brain, and suggest some functional and evolutionary relationship between innate immunity and tautomerization of D-dopachrome in mammalian species
Title: Distribution maps of D-dopachrome tautomerase in the mouse brain.
These data indicate that D-DT is a MIF-like cytokine.
Title: The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126414 (e-PCR)
- UniSTS:163122

D17963 (e-PCR)
- UniSTS:124752

AW553479 (e-PCR)
- UniSTS:208560

AI118089 (e-PCR)
- UniSTS:185838

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-dopachrome decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables phenylpyruvate tautomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylpyruvate tautomerase activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: D-dopachrome decarboxylase

NP_034157.1

EC 4.1.1.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.