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    AZIN1 antizyme inhibitor 1 [ Echinops telfairi (small Madagascar hedgehog) ]

    Gene ID: 101645147, updated on 8-Mar-2024

    Summary

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    Gene symbol
    AZIN1
    Gene description
    antizyme inhibitor 1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Echinops telfairi
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tenrecidae; Tenrecinae; Echinops
    Summary
    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current ASM31398v2 (GCF_000313985.2) Unplaced Scaffold NW_022103896.1 (36160970..36194459)
    101 previous assembly EchTel2.0 (GCF_000313985.1) Unplaced Scaffold NW_004558703.1 (36161002..36194459)

    NW_022103896.1Genomic Context describing neighboring genes Neighboring gene BAALC binder of MAP3K1 and KLF4 Neighboring gene ATPase H+ transporting V1 subunit C1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene KLF transcription factor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Kahana C. Essays Biochem, 2009 Nov 4. PMID 20095969

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ornithine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in putrescine biosynthetic process from ornithine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antizyme inhibitor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291554.1 → NP_001278483.1  antizyme inhibitor 1

      See identical proteins and their annotated locations for NP_001278483.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AAIY03000001
      Conserved Domains (1) summary
      cd06831
      Location:26 → 419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

    2. NM_001301751.1 → NP_001288680.1  antizyme inhibitor 1

      See identical proteins and their annotated locations for NP_001288680.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AAIY03000001
      Conserved Domains (1) summary
      cd06831
      Location:26 → 419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

    RefSeqs of Annotated Genomes: Echinops telfairi Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM31398v2 Primary Assembly

    Genomic

    1. NW_022103896.1 Reference ASM31398v2 Primary Assembly

      Range
      36160970..36194459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030884545.2 → XP_030740405.1  antizyme inhibitor 1 isoform X1

      Conserved Domains (1) summary
      cd06831
      Location:26 → 418
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
    Nucleotide Protein
    Heading Accession and Version

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