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    wrk-1 Ig-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181093, updated on 2-Nov-2024

    Summary

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    Official Symbol
    wrk-1
    Official Full Name
    Ig-like domain-containing protein
    Primary source
    WormBase:WBGene00006942
    Locus tag
    CELE_F41D9.3
    See related
    AllianceGenome:WB:WBGene00006942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be located in cytoplasm. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including coelomocyte; excretory gland cell; hermaphrodite distal tip cell; interfacial epithelial cell; and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See wrk-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (8387442..8392589, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background. Feresten AH, et al. Genetics, 2023 Mar 2. PMID 36573271, Free PMC Article
    2. Developmental regulation of whole cell capacitance and membrane current in identified interneurons in C. elegans. Faumont S, et al. J Neurophysiol, 2006 Jun. PMID 16554520
    3. A novel Eph receptor-interacting IgSF protein provides C. elegans motoneurons with midline guidepost function. Boulin T, et al. Curr Biol, 2006 Oct 10. PMID 17027485
    4. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Lakhina V, et al. Neuron, 2015 Jan 21. PMID 25611510, Free PMC Article
    5. Cell adhesion receptors in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090591

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.
      Title: wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.
    2. WRK-1 acts in eMNs to prevent follower axons from inappropriately crossing the ventral midline.
      Title: A novel Eph receptor-interacting IgSF protein provides C. elegans motoneurons with midline guidepost function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables axon guidance receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ig-like domain-containing protein
    NP_001024647.1
    • Confirmed by transcript evidence
    NP_001024648.1
    • Confirmed by transcript evidence
    NP_001024649.1
    • Confirmed by transcript evidence
    NP_001024651.1
    • Confirmed by transcript evidence
    NP_001360746.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8387442..8392589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029476.4 → NP_001024647.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024647.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZN8, Q8WR44
      Conserved Domains (3) summary
      cd00096
      Location:229 → 302
      Ig; Immunoglobulin domain
      smart00408
      Location:134 → 194
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:25 → 113
      IG_like; Immunoglobulin like

    2. NM_001373391.4 → NP_001360746.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ING2, Q8WR43
      Conserved Domains (3) summary
      smart00408
      Location:134 → 196
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:25 → 113
      IG; Immunoglobulin
      cl11960
      Location:229 → 313
      Ig; Immunoglobulin domain

    3. NM_001029480.6 → NP_001024651.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRR1, Q8WR43
      Conserved Domains (3) summary
      cd00096
      Location:245 → 318
      Ig; Immunoglobulin domain
      smart00408
      Location:142 → 202
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:25 → 113
      IG_like; Immunoglobulin like

    4. NM_001029477.6 → NP_001024648.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZN9, Q8WR43
      Conserved Domains (3) summary
      cd00096
      Location:237 → 310
      Ig; Immunoglobulin domain
      smart00408
      Location:134 → 194
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:25 → 113
      IG_like; Immunoglobulin like

    5. NM_001029478.5 → NP_001024649.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPV0, Q8WR42
      Conserved Domains (2) summary
      smart00408
      Location:134 → 194
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:25 → 113
      IG_like; Immunoglobulin like
    Nucleotide Protein
    Heading Accession and Version

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