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    UBL4B ubiquitin like 4B [ Homo sapiens (human) ]

    Gene ID: 164153, updated on 28-Oct-2024

    Summary

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    Official Symbol
    UBL4Bprovided by HGNC
    Official Full Name
    ubiquitin like 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:32309
    See related
    Ensembl:ENSG00000186150 MIM:611127; AllianceGenome:HGNC:32309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    mouse all
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    Genomic context

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    See UBL4B in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110112443..110113947)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110122566..110124070)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110655065..110656569)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ALX homeobox 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1167 Neighboring gene long intergenic non-protein coding RNA 1397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1461 Neighboring gene Sharpr-MPRA regulatory region 1498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1168 Neighboring gene Sharpr-MPRA regulatory region 9728 Neighboring gene solute carrier family 6 member 17 Neighboring gene SLC6A17 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110740169-110740669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1170 Neighboring gene KCNC4 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. Yang F, et al. Gene Expr Patterns, 2007 Jan. PMID 16872915, Free PMC Article
    2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
    3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. Fox CS, et al. PLoS Genet, 2012. PMID 22589738, Free PMC Article
    4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ25690

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like protein 4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203412.2 → NP_981957.1  ubiquitin-like protein 4B

      See identical proteins and their annotated locations for NP_981957.1

      Status: VALIDATED

      Source sequence(s)
      AA608970, AK098556
      Consensus CDS
      CCDS820.1
      UniProtKB/Swiss-Prot
      Q8N7F7
      Related
      ENSP00000334044.3, ENST00000334179.5
      Conserved Domains (2) summary
      cl00155
      Location:1 → 74
      UBQ; Ubiquitin-like proteins
      cl27330
      Location:20 → 154
      FlhF; Flagellar biosynthesis GTPase FlhF [Cell motility]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      110112443..110113947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      110122566..110124070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N7F7.1 GenPept UniProtKB/Swiss-Prot:Q8N7F7

    Gene LinkOut

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