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    cpa alpha-toxin [ Clostridium perfringens ]

    Gene ID: 69447757, updated on 30-Mar-2024

    Summary

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    Gene symbol
    cpa
    Gene description
    alpha-toxin
    Locus tag
    KLF48_RS00250
    Gene type
    protein coding
    Organism
    Clostridium perfringens (strain: CPI 18-6)
    Lineage
    Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Clostridium
    Also known as
    plc
    Old locus tag
    KLF48_00250
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    Genomic context

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    NZ_CP075979.1Genomic Context describing neighboring genes Neighboring gene glucosaminidase domain-containing protein Neighboring gene YdiU family protein Neighboring gene GTP-binding protein Neighboring gene GTP-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_CP075979.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clostridium perfringens α-toxin specifically induces endothelial cell death by promoting ceramide-mediated apoptosis. Takehara M, et al. Anaerobe, 2020 Oct. PMID 32828915
    2. The Clostridium perfringens alpha-toxin. Titball RW, et al. Anaerobe, 1999 Apr. PMID 16887662
    3. The biochemistry of bacterial toxins: The lecithinase activity of Cl. welchii toxins. Macfarlane MG, et al. Biochem J, 1941 Sep. PMID 16747456, Free PMC Article
    4. Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region. Eaton JT, et al. J Mol Biol, 2002 May 31. PMID 12051905
    5. Structure and function of clostridial phospholipases C. Jepson M, et al. Microbes Infect, 2000 Aug. PMID 11008117

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    alpha-toxin
    WP_004456772.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_CP075979.1 Reference assembly

      Range
      52858..54054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_004456772.1 alpha-toxin [Clostridium perfringens]

      See identical proteins and their annotated locations for WP_004456772.1

      UniProtKB/TrEMBL
      B1BTD4, B5AFC0, Q1HXC5, Q1HXD6, Q1HXR6
      Conserved Domains (2) summary
      smart00770
      Location:1 → 273
      Zn_dep_PLPC; Zinc dependent phospholipase C (alpha toxin)
      cd00113
      Location:284 → 396
      PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
    Nucleotide Protein
    Heading Accession and Version