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    HCK HCK proto-oncogene, Src family tyrosine kinase [ Colobus angolensis palliatus ]

    Gene ID: 105524623, updated on 11-Apr-2024

    Summary

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    Gene symbol
    HCK
    Gene description
    HCK proto-oncogene, Src family tyrosine kinase
    See related
    Ensembl:ENSCANG00000038101
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Colobus angolensis palliatus (sub-species: palliatus)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Colobus
    Orthologs
    human mouse all
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    Genomic context

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    See HCK in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    100 current Cang.pa_1.0 (GCF_000951035.1) Unplaced Scaffold NW_012112475.1 (2676518..2729801, complement)

    NW_012112475.1Genomic Context describing neighboring genes Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene transmembrane 9 superfamily member 4 Neighboring gene uncharacterized LOC105524634 Neighboring gene CCM2 like scaffold protein Neighboring gene XK related 7 Neighboring gene p53 and DNA damage regulated 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_012112475.1 Unplaced Scaffold Reference Cang.pa_1.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase HCK

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Colobus angolensis palliatus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Cang.pa_1.0

    Genomic

    1. NW_012112475.1 Reference Cang.pa_1.0

      Range
      2676518..2729801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011959967.1 → XP_011815357.1  tyrosine-protein kinase HCK isoform X1

      UniProtKB/TrEMBL
      A0A2K5JJX3
      Related
      ENSCANP00000029145.1, ENSCANT00000052273.1
      Conserved Domains (4) summary
      cd10363
      Location:118 → 221
      SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
      pfam07714
      Location:240 → 489
      Pkinase_Tyr; Protein tyrosine kinase
      cl17036
      Location:60 → 115
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:232 → 502
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011959975.1 → XP_011815365.1  tyrosine-protein kinase HCK isoform X2

      UniProtKB/TrEMBL
      A0A2K5JJX3
      Conserved Domains (3) summary
      cd10363
      Location:36 → 139
      SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
      cl17036
      Location:1 → 33
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:150 → 420
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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