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    Unc50 unc-50 homolog [ Mus musculus (house mouse) ]

    Gene ID: 67387, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Unc50provided by MGI
    Official Full Name
    unc-50 homologprovided by MGI
    Primary source
    MGI:MGI:1914637
    See related
    Ensembl:ENSMUSG00000026111 AllianceGenome:MGI:1914637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    URP; GMH1; UNCL; 1110002A21Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Located in Golgi apparatus. Orthologous to human UNC50 (unc-50 inner nuclear membrane RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 34.7), placenta adult (RPKM 30.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Unc50 in Genome Data Viewer
    Location:
    1 B; 1 15.46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37469220..37478068)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37430139..37438987)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930439A04 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37374616-37374799 Neighboring gene inositol polyphosphate-4-phosphatase, type I Neighboring gene STARR-seq mESC enhancer starr_00675 Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene mannoside acetylglucosaminyltransferase 4, isoenzyme A Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37528102-37528303 Neighboring gene STARR-positive B cell enhancer ABC_E1540 Neighboring gene G1 to S phase transition pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1541 Neighboring gene STARR-seq mESC enhancer starr_00677 Neighboring gene predicted gene, 39627

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-50 homolog
    Names
    PDLs22
    periodontal ligament-specific protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356528.1 → NP_001343457.1  protein unc-50 homolog

      Status: VALIDATED

      Source sequence(s)
      AC084390
      Consensus CDS
      CCDS14892.1
      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Related
      ENSMUSP00000110575.4, ENSMUST00000114925.10
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family

    2. NM_026123.4 → NP_080399.1  protein unc-50 homolog

      See identical proteins and their annotated locations for NP_080399.1

      Status: VALIDATED

      Source sequence(s)
      AC084390, AK135885, AW124245
      Consensus CDS
      CCDS14892.1
      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Related
      ENSMUSP00000027285.7, ENSMUST00000027285.13
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      37469220..37478068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496220.5 → XP_006496283.1  protein unc-50 homolog isoform X1

      See identical proteins and their annotated locations for XP_006496283.1

      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family

    2. XM_036153127.1 → XP_036009020.1  protein unc-50 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Related
      ENSMUSP00000123684.2, ENSMUST00000144617.8
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family

    3. XM_030242345.2 → XP_030098205.1  protein unc-50 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family

    4. XM_006496221.5 → XP_006496284.1  protein unc-50 homolog isoform X1

      See identical proteins and their annotated locations for XP_006496284.1

      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Related
      ENSMUSP00000113135.2, ENSMUST00000118059.3
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family

    5. XM_006496223.5 → XP_006496286.1  protein unc-50 homolog isoform X1

      See identical proteins and their annotated locations for XP_006496286.1

      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family

    6. XM_036153129.1 → XP_036009022.1  protein unc-50 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9CQ61
      UniProtKB/TrEMBL
      D3YXX4
      Conserved Domains (1) summary
      pfam05216
      Location:34 → 255
      UNC-50; UNC-50 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ61.1 GenPept UniProtKB/Swiss-Prot:Q9CQ61

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