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    Lyzl6 lysozyme-like 6 [ Mus musculus (house mouse) ]

    Gene ID: 69444, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Lyzl6provided by MGI
    Official Full Name
    lysozyme-like 6provided by MGI
    Primary source
    MGI:MGI:1916694
    See related
    Ensembl:ENSMUSG00000020945 AllianceGenome:MGI:1916694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lyc1; Lyzb; 1700023H08Rik
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to bacterium and fusion of sperm to egg plasma membrane involved in single fertilization. Located in sperm midpiece. Orthologous to human LYZL6 (lysozyme like 6). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis adult (RPKM 87.6) See more
    Orthologs
    human all
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    Genomic context

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    See Lyzl6 in Genome Data Viewer
    Location:
    11 E1; 11 67.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103521894..103529716, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103631068..103638890, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30850 Neighboring gene leucine rich repeat containing 37A Neighboring gene STARR-seq mESC enhancer starr_30851 Neighboring gene STARR-seq mESC enhancer starr_30852 Neighboring gene leucine rich repeat containing 37 Neighboring gene STARR-seq mESC enhancer starr_30853 Neighboring gene STARR-seq mESC enhancer starr_30854 Neighboring gene STARR-seq mESC enhancer starr_30855 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 1700072I22 gene Neighboring gene reprimo-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterisation of Lyzls in mice and antibacterial properties of human LYZL6. Wei J, et al. Asian J Androl, 2013 Nov. PMID 24013621, Free PMC Article
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme-like protein 6
    Names
    lysozyme b
    lysozyme-like protein 1
    NP_001343401.1
    NP_081359.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356472.2 → NP_001343401.1  lysozyme-like protein 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AK006279, AV254473, BY092087
      Consensus CDS
      CCDS25519.1
      UniProtKB/Swiss-Prot
      Q9DA11
      UniProtKB/TrEMBL
      A0A077S2U3
      Related
      ENSMUSP00000102628.2, ENSMUST00000107014.8
      Conserved Domains (1) summary
      cd00119
      Location:21 → 142
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    2. NM_027083.3 → NP_081359.1  lysozyme-like protein 6 precursor

      See identical proteins and their annotated locations for NP_081359.1

      Status: VALIDATED

      Source sequence(s)
      AV254473, BC048617, BY092087
      Consensus CDS
      CCDS25519.1
      UniProtKB/Swiss-Prot
      Q9DA11
      UniProtKB/TrEMBL
      A0A077S2U3
      Related
      ENSMUSP00000021328.8, ENSMUST00000021328.8
      Conserved Domains (1) summary
      cd00119
      Location:21 → 142
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103521894..103529716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DA11.1 GenPept UniProtKB/Swiss-Prot:Q9DA11

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